哮喘与炎症性肠病的后续发展相关：基于人群的病例对照研究。

Asthma Is Associated With Subsequent Development of Inflammatory Bowel Disease: A Population-based Case-Control Study.

机构信息

Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; Synder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada; O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada.

Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada.

出版信息

Clin Gastroenterol Hepatol. 2017 Sep;15(9):1405-1412.e3. doi: 10.1016/j.cgh.2017.02.042. Epub 2017 Mar 23.

DOI:10.1016/j.cgh.2017.02.042

PMID:28344063

Abstract

BACKGROUND & AIMS: Asthma and the inflammatory bowel diseases (IBD) each arise through complex interactions between genetic and environmental factors, and share many environmental risk factors. We examined the association between asthma and Crohn's disease or ulcerative colitis.

METHODS

We performed a population-based case-control study using health administrative data from the province of Alberta, Canada. The odds of a diagnosis of asthma preceding the diagnosis of either Crohn's disease (N = 3087) or ulcerative colitis (N = 2377) were compared with the odds of diagnosis of asthma among persons without IBD (N = 402,800) using logistic regression. Effect measure modification by age at diagnosis of IBD (16 years or less, 17-40 years, or older than 40 years) was tested using a likelihood ratio test.

RESULTS

A diagnosis of asthma was associated with increased odds of incident Crohn's disease (adjusted odds ratio [OR], 1.45; 95% confidence interval [CI], 1.31-1.60). No effect measure modification was observed for age at diagnosis for Crohn's disease (P = .42). However, we observed effect measure modification by age at diagnosis for ulcerative colitis (P = .0103), with an adjusted OR of 1.49 (95% CI, 1.08-2.07) among individuals diagnosed at an age of 16 years or less (OR) and an adjusted OR of 1.57 (95% CI, 1.31-1.89) among individuals diagnosed at an age older than 40 years. However, there was no association between asthma and ulcerative colitis among individuals diagnosed between ages 17 and 40 (adjusted OR, 1.05; 95% CI, 0.86-1.26).

CONCLUSIONS

In a population-based case-control study, we associated asthma with Crohn's disease, and with early and late-onset ulcerative colitis.

摘要

背景与目的

哮喘和炎症性肠病（IBD）均由遗传和环境因素的复杂相互作用引起，并且具有许多共同的环境危险因素。我们研究了哮喘与克罗恩病或溃疡性结肠炎之间的关系。

方法

我们使用来自加拿大艾伯塔省的健康管理数据进行了一项基于人群的病例对照研究。使用逻辑回归比较了哮喘诊断之前诊断为克罗恩病（N=3087）或溃疡性结肠炎（N=2377）的患者与没有 IBD 的患者（N=402800）的哮喘诊断几率。使用似然比检验测试年龄（16 岁或以下、17-40 岁或 40 岁以上）对 IBD 诊断的影响。

结果

哮喘诊断与克罗恩病的发病率增加有关（调整后的比值比[OR]，1.45；95%置信区间[CI]，1.31-1.60）。未观察到克罗恩病诊断年龄的效应修饰（P=.42）。然而，我们观察到溃疡性结肠炎诊断年龄的效应修饰（P=.0103），16 岁或以下诊断的个体调整后的 OR 为 1.49（95%CI，1.08-2.07），40 岁以上诊断的个体调整后的 OR 为 1.57（95%CI，1.31-1.89）。然而，在 17-40 岁诊断的个体中，哮喘与溃疡性结肠炎之间没有关联（调整后的 OR，1.05；95%CI，0.86-1.26）。