University of Wyoming, School of Pharmacy, College of Health Science and Center for Cardiovascular Research and Alternative Medicine, Laramie, WY 82071, USA.
University of Wyoming, School of Pharmacy, College of Health Science and Center for Cardiovascular Research and Alternative Medicine, Laramie, WY 82071, USA.
Biochim Biophys Acta Mol Basis Dis. 2017 Aug;1863(8):2070-2077. doi: 10.1016/j.bbadis.2017.03.013. Epub 2017 Mar 24.
Diabetic cardiomyopathy is a chronic and irreversible heart complication in diabetic patients, and is characterized by complex pathophysiologic events including early diastolic dysfunction, cardiac hypertrophy, ventricular dilation and systolic dysfunction, eventually resulting in heart failure. Despite these characteristics, the underlying mechanisms leading to diabetic cardiomyopathy are still elusive. Recent studies have implicated microRNA, a small and highly conserved non-coding RNA molecule, in the etiology of diabetes and its complications, suggesting a potentially novel approach for the diagnosis and treatment of diabetic cardiomyopathy. This brief review aims at capturing recent studies related to the role of microRNA in diabetic cardiomyopathy. This article is part of a Special Issue entitled: Genetic and epigenetic control of heart failure - edited by Jun Ren & Megan Yingmei Zhang.
糖尿病性心肌病是糖尿病患者的一种慢性且不可逆转的心脏并发症，其特征是存在包括舒张早期功能障碍、心脏肥大、心室扩张和收缩功能障碍在内的复杂病理生理事件，最终导致心力衰竭。尽管具有这些特征，但导致糖尿病性心肌病的潜在机制仍不清楚。最近的研究表明，微小 RNA（一种小型且高度保守的非编码 RNA 分子）与糖尿病及其并发症的病因有关，这提示了一种用于糖尿病性心肌病的诊断和治疗的潜在新方法。本综述旨在介绍与微小 RNA 在糖尿病性心肌病中的作用相关的最新研究。本文是由 Jun Ren 和 Megan Yingmei Zhang 编辑的特刊“心力衰竭的遗传和表观遗传控制”的一部分。
