Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases of China, Chinese Academy of Medical Sciences and Peking Union Medical College, Hypertension Center, Fuwai Hospital, Xicheng District, North Lishi Road No. 167, Beijing 100037, China.
Biochim Biophys Acta Mol Basis Dis. 2017 Aug;1863(8):2019-2030. doi: 10.1016/j.bbadis.2016.11.034. Epub 2016 Dec 1.
MicroRNAs are small non-coding RNA molecules that regulate gene expression by inhibiting mRNA translation and/or inducing mRNA degradation. In the past decade, many in vitro and in vivo studies have explored the involvement of microRNAs in various cardiovascular diseases. In this paper, studies focused upon the target genes and functionality of miRNAs in the pathophysiological processes of heart failure are reviewed. The selected miRNAs are categorized according to the biological relevance of their target genes in relation to four cardiovascular pathologies, namely angiogenesis, cardiac hypertrophy, fibrosis and apoptosis. This review illustrates the involvement of miRNAs in different biological signaling pathways and provides an overview of current understanding of the roles of miRNAs in cardiovascular health and diseases. This article is part of a Special Issue entitled: Genetic and epigenetic control of heart failure - edited by Jun Ren & Megan Yingmei Zhang.
微小 RNA 是一类通过抑制 mRNA 翻译和/或诱导 mRNA 降解来调节基因表达的小非编码 RNA 分子。在过去的十年中，许多体外和体内研究都探讨了微小 RNA 在各种心血管疾病中的作用。本文综述了微小 RNA 在心力衰竭病理生理过程中的靶基因和功能。所选微小 RNA 根据其靶基因在四种心血管病理，即血管生成、心肌肥厚、纤维化和细胞凋亡中的生物学相关性进行分类。这篇综述说明了微小 RNA 参与不同的生物信号通路，并概述了目前对微小 RNA 在心血管健康和疾病中的作用的理解。本文是由 Jun Ren 和 Megan Yingmei Zhang 编辑的特刊“心力衰竭的遗传和表观遗传调控”的一部分。
