Toikkanen S, Eerola E, Ekfors T O
Department of Pathology, University of Turku, Finland.
J Clin Pathol. 1988 Mar;41(3):300-3. doi: 10.1136/jcp.41.3.300.
The DNA stemline of 45 mucinous breast carcinomas was determined by flow cytometry using paraffin embedded archival tissue sections. The material consisted of 26 pure mucinous and 19 mixed mucinous carcinomas. The patients were followed up for at least 15 years or until death. Nearly all pure mucinous carcinomas had a normal DNA stemline (25 of 26) with only one aneuploid tumour. Mixed mucinous carcinomas had a DNA content resembling that of common ductal carcinoma with 11 aneuploid tumours. Aneuploid tumours tended to be of higher grade and stage than diploid tumours. The survival of patients with pure mucinous carcinoma was better than that of patients with mixed mucinous carcinoma. Mucinous carcinoma should be classified as such only if it is a pure mucinous carcinoma.
采用石蜡包埋存档组织切片，通过流式细胞术测定了45例黏液性乳腺癌的DNA干系。材料包括26例纯黏液性癌和19例混合性黏液性癌。对患者进行了至少15年的随访或直至死亡。几乎所有纯黏液性癌都有正常的DNA干系（26例中的25例），只有1例非整倍体肿瘤。混合性黏液性癌的DNA含量与常见导管癌相似，有11例非整倍体肿瘤。非整倍体肿瘤往往比二倍体肿瘤的分级和分期更高。纯黏液性癌患者的生存率高于混合性黏液性癌患者。黏液性癌仅在为纯黏液性癌时才应如此分类。
