Comprehensive Breast Cancer Center, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua 50006, Taiwan.
World J Surg Oncol. 2013 Jun 14;11:139. doi: 10.1186/1477-7819-11-139.
Pure mucinous carcinoma (MC) is found in about 3.5% of all newly diagnosed breast cancer patients in Taiwan. MC is a relatively rare malignancy of breast cancer, and its nature, behaviors, treatment pattern and long-term follow-up are not well understood. The study aimed to investigate the incidence rate, treatment patterns, and prognostic factors of MC of the breast and the clinical long-term outcomes compared with infiltrating ductal carcinoma not otherwise specified (IDC) in the middle and south Taiwanese women.
Data from 93 patients with breast MC were retrospectively reviewed and the clinicopathologic characteristics and survival status were compared with those of 2,674 patients with IDC.
The expression of hormonal receptor was higher in MC than those in IDC (P <0.001). MC also demonstrated lower Her2/neu gene over-expression (P = 0.023), less axillary lymph node involvement (P <0.0001), lymphovascular invasion (P <0.0001) and higher 10-year overall survival rate (P = 0.042), when compared with those of IDC.
Our data confirm the less aggressive behavior of MC compared to IDC. MC showed favorable clinicopathologic characteristics in tumor grade, hormone receptor status and lymph node involvement in the middle and south Taiwanese women.
在台湾，约有 3.5%的新诊断乳腺癌患者为纯黏液癌（MC）。MC 是乳腺癌中相对罕见的恶性肿瘤，其性质、行为、治疗模式和长期随访情况尚未得到很好的了解。本研究旨在调查台湾中南部女性乳腺癌 MC 的发病率、治疗模式和预后因素，并与非特殊型浸润性导管癌（IDC）进行临床长期结局比较。
回顾性分析了 93 例乳腺 MC 患者的临床病理特征和生存状况，并与 2674 例 IDC 患者进行比较。
MC 患者的激素受体表达率高于 IDC（P<0.001）。MC 患者的 Her2/neu 基因过表达率较低（P=0.023），腋窝淋巴结受累（P<0.0001）、脉管侵犯（P<0.0001）较少，10 年总生存率较高（P=0.042）。
与 IDC 相比，MC 确实具有侵袭性较低的行为。在台湾中南部女性中，MC 表现出较好的肿瘤分级、激素受体状态和淋巴结受累的临床病理特征。
