Piura B, Zirkin H J
Division of Obstetrics and Gynecology, Soroka Medical Center, Beer-Sheva, Israel.
J Dermatol Surg Oncol. 1988 May;14(5):533-7. doi: 10.1111/j.1524-4725.1988.tb01148.x.
Vulvar Paget's disease, in contrast to its mammary counterpart, has been found to be associated with an underlying apocrine sweat gland carcinoma in about only 1/4 of the cases. There are two principal theories regarding the pathogenesis of extramammary Paget's disease: (1) intraepidermal origin of the Paget cells occurring independently of, or concomitantly with, an underlying apocrine gland carcinoma, and (2) the migration or metastasis of Paget cells into the epidermis from the underlying apocrine glands and/or ducts. A case of vulvar Paget's disease that, in our opinion, supports the theory of apocrine gland origin of Paget cells is reported herein.
与乳腺派杰氏病不同，外阴派杰氏病仅在约四分之一的病例中被发现与潜在的大汗腺癌相关。关于乳腺外派杰氏病的发病机制有两种主要理论：（1）派杰细胞的表皮内起源独立于或与潜在的大汗腺癌同时发生；（2）派杰细胞从潜在的大汗腺和/或导管迁移或转移至表皮。本文报告了一例我们认为支持派杰细胞起源于大汗腺这一理论的外阴派杰氏病病例。
