Synthesis and antimicrobial properties of 4-acylaminobenzenethiosulfoacid S-esters.

A series of esters of 4-acetyl, 4-trifluoroacetyl- and 4-(3-chloropropionyl)aminobenzenethiosulfoacids (twenty-four compounds) were synthesized and characterized by elemental analysis, H NMR and IR spectroscopy. The antibacterial activity of the novel candidates has been screened using the agar diffusion or serial dilution methods against representative Gram-positive (, , , sp., ), Gram-negative ( sp., , , , , ) bacteria and fungi (, , , , , , , ). Particular potency has been discovered against all tested pathogenic bacteria and fungi by compounds and at nanomolar concentrations. Some appropriate effect of thiosulfoesters structure upon their antimicrobial activity was determined.