肌肉生长抑制素在哺乳动物脂肪量调节中的作用。
The function of myostatin in the regulation of fat mass in mammals.
作者信息
Deng Bing, Zhang Feng, Wen Jianghui, Ye Shengqiang, Wang Lixia, Yang Yu, Gong Ping, Jiang Siwen
机构信息
Institute of Animal Husbandry and Veterinary Science, Wuhan Academy of Agricultural Science and Technology, Wuhan, Hubei 430208 People's Republic of China.
Key Laboratory of Swine Genetics and Breeding of the Agricultural Ministry and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070 People's Republic of China.
出版信息
Nutr Metab (Lond). 2017 Mar 21;14:29. doi: 10.1186/s12986-017-0179-1. eCollection 2017.
Myostatin (MSTN), also referred to as growth and differentiation factor-8, is a protein secreted in muscle tissues. Researchers believe that its primary function is in negatively regulating muscle because a mutation in its coding region can lead to the famous double muscle trait in cattle. Muscle and adipose tissue develop from the same mesenchymal stem cells, and researchers have found that MSTN is expressed in fat tissues and plays a key role in adipogenesis. Interestingly, MSTN can exert a dual function, either inhibiting or promoting adipogenesis, according to the situation. Due to its potential function in controlling body fat mass, MSTN has attracted the interest of researchers. In this review, we explore its function in regulating adipogenesis in mammals, including preadipocytes, multipotent stem cells and fat mass.
肌生成抑制素（MSTN），也被称为生长分化因子8，是一种在肌肉组织中分泌的蛋白质。研究人员认为其主要功能是对肌肉进行负调控，因为其编码区域的突变会导致牛出现著名的双肌性状。肌肉和脂肪组织都由相同的间充质干细胞发育而来，研究人员发现MSTN在脂肪组织中表达，并在脂肪生成中起关键作用。有趣的是，根据具体情况，MSTN可以发挥双重功能，既抑制也促进脂肪生成。由于其在控制体脂量方面的潜在功能，MSTN已引起研究人员的兴趣。在这篇综述中，我们探讨了它在调节哺乳动物脂肪生成中的功能，包括前脂肪细胞、多能干细胞和脂肪量。
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