Key Laboratory of Adaptation and Evolution of Plateau Biota, Qinghai Provincial Key Laboratory of Animal Ecological Genomics, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Genes (Basel). 2024 Jul 15;15(7):921. doi: 10.3390/genes15070921.
Tibetan sheep are vital to the ecosystem and livelihood of the Tibetan Plateau; however, traditional breeding methods limit their production and growth. Modern molecular breeding techniques are required to improve these traits. This study identified a single nucleotide polymorphism (SNP) in myostatin () and in Tibetan sheep. The findings indicated notable associations between genotypes and growth traits including birth weight (BW), body length (BL), chest width (ChW), and chest circumference (ChC), as well as a particularly strong association with cannon circumference (CaC) at 2 months of age. Conversely, polymorphisms did not have a significant impact on Tibetan sheep. Moreover, the analyses revealed a significant association between sex and BW or hip width (HW) at 2 months of age and ChW, ChC, and CaC at 4 months of age. Furthermore, the study's results suggested that the genotype of as a GA was associated with a notable sex effect on BW, while the genotype of (CC) showed a significant impact of sex on CaC at 2 months of age. These results indicated that the SNP of could potentially serve as a molecular marker for early growth traits in Tibetan sheep.
藏羊对青藏高原的生态系统和生计至关重要；然而，传统的繁殖方法限制了它们的生产和生长。需要现代分子育种技术来改进这些特性。本研究在藏羊的肌生成抑制素（）和基因中鉴定出一个单核苷酸多态性（SNP）。研究结果表明，基因型与生长性状（包括初生重（BW）、体高（BL）、胸宽（ChW）和胸围（ChC））之间存在显著关联，与 2 月龄的管围（CaC）之间存在特别强的关联。相比之下，多态性对藏羊没有显著影响。此外，分析表明 2 月龄时性别与 BW 或髋宽（HW）以及 4 月龄时 ChW、ChC 和 CaC 之间存在显著关联。此外，研究结果表明，2 月龄时，基因型为 GA 的 与 BW 的性别效应显著相关，而基因型为 CC 的 对 2 月龄时的 CaC 有显著的性别影响。这些结果表明，SNP 可能成为藏羊早期生长性状的分子标记。
