Shipman William D, Dasoveanu Dragos C, Lu Theresa T
Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA; Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.
Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, USA; Physiology, Biophysics, and Systems Biology Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.
F1000Res. 2017 Feb 28;6:196. doi: 10.12688/f1000research.10595.1. eCollection 2017.
Tertiary lymphoid organs are found at sites of chronic inflammation in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. These organized accumulations of T and B cells resemble secondary lymphoid organs and generate autoreactive effector cells. However, whether they contribute to disease pathogenesis or have protective functions is unclear. Here, we discuss how tertiary lymphoid organs can generate potentially pathogenic cells but may also limit the extent of the response and damage in autoimmune disease.
三级淋巴器官存在于自身免疫性疾病（如系统性红斑狼疮和类风湿性关节炎）的慢性炎症部位。这些T细胞和B细胞的有组织聚集类似于二级淋巴器官，并产生自身反应性效应细胞。然而，它们是否参与疾病发病机制或具有保护功能尚不清楚。在这里，我们讨论三级淋巴器官如何产生潜在的致病细胞，但也可能限制自身免疫性疾病中的反应程度和损伤。
