J Clin Invest. 2022 Jul 1;132(13). doi: 10.1172/JCI160657.
Lupus nephritis (LN) is common in people with systemic lupus erythematosus (SLE) and advances, almost invariably, to end-stage renal disease (ESRD). In this issue of the JCI, Abraham, Durkee, et al. presented a large-scale immune cell landscape of kidney biopsies from patients with LN by combining multiplexed confocal microscopy imaging with customized computer vision and quantification. The presence of diverse CD4- T cells in small neighborhoods, but not of B cells or CD4+ T cells in large neighborhoods, is linked to the development of ESRD. Unexpectedly, B cells in the kidney heralded a good prognosis. The precise location of different types of immune cells allows inference on possible interactions between different immune cells and also between immune and kidney-resident cells. The data have important implications on the development of prognostic tools and effective targeted therapies in patients with LN.
狼疮性肾炎 (LN) 在系统性红斑狼疮 (SLE) 患者中很常见，几乎无一例外地进展为终末期肾病 (ESRD)。在本期 JCI 中，Abraham、Durkee 等人通过将多重共聚焦显微镜成像与定制的计算机视觉和定量分析相结合，呈现了 LN 患者肾活检的大规模免疫细胞图谱。小邻里中存在多种 CD4-T 细胞，但大邻里中不存在 B 细胞或 CD4+T 细胞，与 ESRD 的发生有关。出乎意料的是，肾脏中的 B 细胞预示着良好的预后。不同类型免疫细胞的精确位置可以推断不同免疫细胞之间以及免疫细胞与肾脏固有细胞之间可能的相互作用。这些数据对 LN 患者预后工具的开发和有效靶向治疗具有重要意义。
