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两种剂量的低分子量肝素PK 10169预防103例股骨颈骨折治疗期间血栓栓塞事件的对比研究

[Comparative study of 2 dosages of low molecular weight heparin, PK 10169, in the prevention of thromboembolic incidents during treatment of 103 femur neck fractures].

作者信息

Barsotti J, Dabo B, Andreu J, Favard L, Rosset P, Leroy J, Delahousse R, Alison D

机构信息

Service de Chirurgie générale et Traumatologie, Hôpital Trousseau, Chambray-les-Tours.

出版信息

J Mal Vasc. 1987;12 Suppl B:96-8.

PMID:2834501
Abstract

Results of this study in the elderly with fractures of femoral neck, in whom their exists an enhanced thrombogenic risk, showed that the dose of 40 mg per 24 hours as one or two divided injections of enoxaparine was as effective as adapted subcutaneous doses of calcium heparinate. It was also less iatrogenic and easier to manage (biological assays were of little use apart from platelet counts). Clinical evidence of pulmonary embolism, or mortality, were not observed in this series of 103 patients.

摘要

本研究针对存在血栓形成风险增加的老年股骨颈骨折患者,结果显示,每24小时40毫克依诺肝素分一次或两次注射的剂量,与调整后的皮下注射肝素钙剂量效果相同。而且它的医源性损伤更小,更易于管理(除血小板计数外,生物学检测作用不大)。在这103例患者中,未观察到肺栓塞的临床证据或死亡情况。

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