Kiviluoto O, Julkunen H, Honkonen K
Zentralbl Chir. 1980;105(7):460-4.
The value of low dosage heparin in preventing venous thromboembolism was studied in 150 patients with proximal femoral fractures. This was a prospective, randomized, clinical trial, consisting of 116 women and 34 men with a mean age of 73 years (38 to 92). 5000 units of subcutaneous heparin was given twice a day for a fortnight to the heparinized group and the control group was left without. The heparin was commenced on admission to hospital. Deep venous thromboses (D. V. T.) and pulmonary embolism (P. E.) was diagnosed on clinical grounds. Fatal P. E. was verified by necropsy. There was significantly less D. V. T. in the heparinized group than in the control group (p < 0.01) and the incidence of P. E. was smaller in the heparinized group, 0 and 4 per cent respectively. This difference is not statistically significant. There were no significant differences in the amount of blood needed. We recommend routine use of low dosage heparin started on admission to hospital in proximal femoral fractures.
对150例股骨近端骨折患者进行了低剂量肝素预防静脉血栓栓塞价值的研究。这是一项前瞻性、随机临床试验，包括116名女性和34名男性，平均年龄73岁（38至92岁）。肝素化组每天皮下注射5000单位肝素，共两周，对照组不进行任何处理。肝素在入院时开始使用。根据临床症状诊断深静脉血栓形成（D.V.T.）和肺栓塞（P.E.）。致命性肺栓塞通过尸检证实。肝素化组的深静脉血栓形成明显少于对照组（p<0.01），肝素化组的肺栓塞发生率较低，分别为0%和4%。这种差异无统计学意义。两组所需输血量无显著差异。我们建议对股骨近端骨折患者在入院时常规使用低剂量肝素。
