a 1st Department of Psychiatry , Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens , Athens , Greece.
Int J Psychiatry Clin Pract. 2017 Sep;21(3):181-187. doi: 10.1080/13651501.2017.1305111. Epub 2017 Mar 27.
A few case-reports have previously described transient psychotic-like symptoms in non-psychotic patients with panic disorder (PD). We aimed to systematically explore whether PD patients without any current or past psychosis can be differentiated according to the severity of 'psychoticism' as a dimension, comprising clinical features such as psychotic-like experiences, increased social alienation, hostility and suspiciousness.
Sample included 35 (female = 26) medication-free, non-psychotic patients consecutively referred from our Department's Outpatient Clinic for acute symptoms of DSM-5 PD with (PDA; N = 29) or without concurrent agoraphobia. Psychometric measures included the Symptom Checklist-90-Revised (SCL-90-R), Agoraphobic Cognitions Questionnaire (ACQ), Body Sensations Questionnaire (BSQ), and panic attacks during last 21 days PA-21d.
Multiple regression analysis (forward stepwise) revealed that, among all SCL-90-R subscales, the psychoticism-subscale was most significantly associated with panic-related beliefs included in the ACQ, while significant associations emerged between the paranoid ideation-subscale and the ACQ and BSQ measures. Moreover, significant correlations emerged between the SCL-90-R psychoticism-subscale and all three measures of PD symptoms (ACQ, BSQ, PA-21d) and between the SCL-90-R paranoid ideation-subscale and both the ACQ and BSQ.
This significant association between levels of psychoticism and severity of panic symptoms may reflect a more severe subtype of PD.
先前有一些病例报告描述了非精神病性惊恐障碍（PD）患者出现短暂的精神病样症状。我们旨在系统地探索 PD 患者是否可以根据“精神病性”严重程度进行区分，作为一个维度，包括精神病样体验、社交疏远增加、敌意和多疑等临床特征。
样本包括 35 名（女性=26 名）未服用药物的非精神病性患者，他们连续从我们部门的门诊就诊，出现 DSM-5 PD 的急性症状，伴有（PDA；N=29）或不伴有同时发生的广场恐惧症。心理测量包括症状清单 90 修订版（SCL-90-R）、广场恐惧症认知问卷（ACQ）、身体感觉问卷（BSQ）和过去 21 天内的惊恐发作（PA-21d）。
多元回归分析（向前逐步）显示，在 SCL-90-R 所有子量表中，精神病性子量表与 ACQ 中包含的与惊恐相关的信念最显著相关，而偏执观念子量表与 ACQ 和 BSQ 测量之间也出现了显著关联。此外，SCL-90-R 精神病性子量表与 PD 症状的所有三个测量指标（ACQ、BSQ、PA-21d）之间以及 SCL-90-R 偏执观念子量表与 ACQ 和 BSQ 之间都存在显著相关性。
精神病性水平与惊恐症状严重程度之间的这种显著关联可能反映了 PD 的更严重亚型。
