Pompa Andrea, De Marchis Francesca, Pallotta Maria Teresa, Benitez-Alfonso Yoselin, Jones Alexandra, Schipper Kerstin, Moreau Kevin, Žárský Viktor, Di Sansebastiano Gian Pietro, Bellucci Michele
Institute of Biosciences and Bioresources-Research Division of Perugia, National Research Council (CNR), via della Madonna Alta 130, 06128 Perugia, Italy.
Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
Int J Mol Sci. 2017 Mar 25;18(4):703. doi: 10.3390/ijms18040703.
Many proteins and cargoes in eukaryotic cells are secreted through the conventional secretory pathway that brings proteins and membranes from the endoplasmic reticulum to the plasma membrane, passing through various cell compartments, and then the extracellular space. The recent identification of an increasing number of leaderless secreted proteins bypassing the Golgi apparatus unveiled the existence of alternative protein secretion pathways. Moreover, other unconventional routes for secretion of soluble or transmembrane proteins with initial endoplasmic reticulum localization were identified. Furthermore, other proteins normally functioning in conventional membrane traffic or in the biogenesis of unique plant/fungi organelles or in plasmodesmata transport seem to be involved in unconventional secretory pathways. These alternative pathways are functionally related to biotic stress and development, and are becoming more and more important in cell biology studies in yeast, mammalian cells and in plants. The city of Lecce hosted specialists working on mammals, plants and microorganisms for the inaugural meeting on "Unconventional Protein and Membrane Traffic" (UPMT) during 4-7 October 2016. The main aim of the meeting was to include the highest number of topics, summarized in this report, related to the unconventional transport routes of protein and membranes.
真核细胞中的许多蛋白质和货物是通过传统分泌途径分泌的，该途径将蛋白质和膜从内质网运输到质膜，经过各种细胞区室，然后到达细胞外空间。最近发现越来越多的无信号肽分泌蛋白绕过高尔基体，揭示了替代蛋白分泌途径的存在。此外，还发现了其他非传统途径，用于分泌最初定位于内质网的可溶性或跨膜蛋白。此外，其他通常在传统膜运输、独特植物/真菌细胞器生物发生或胞间连丝运输中起作用的蛋白质似乎也参与了非传统分泌途径。这些替代途径在功能上与生物胁迫和发育相关，并且在酵母、哺乳动物细胞和植物的细胞生物学研究中变得越来越重要。2016年10月4日至7日，莱切市举办了“非传统蛋白质和膜运输”（UPMT）首届会议，来自哺乳动物、植物和微生物领域的专家齐聚一堂。本次会议的主要目的是涵盖与蛋白质和膜的非传统运输途径相关的尽可能多的主题，本报告对此进行了总结。
