Seo Yongsuk, Gerhart Hayden D, Vaughan Jeremiah, Kim Jung-Hyun, Glickman Ellen L
1 Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health , National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania.
2 Department of Exercise Physiology, Kent State University , Kent, Ohio.
High Alt Med Biol. 2017 Jun;18(2):185-190. doi: 10.1089/ham.2016.0139. Epub 2017 Mar 27.
Seo, Yongsuk, Hayden D. Gerhart, Jeremiah Vaughan, Jung-Hyun Kim, and Ellen L. Glickman. Does acute normobaric hypoxia induce anapyrexia in adult humans? High Alt Med Biol. 18:185-190, 2017.-Exposure to hypoxia is known to induce a reduction in core body temperature as a protective mechanism, which has been shown in both animals and humans. The purpose of this study was to test if acute exposure to normobaric hypoxia (NH) induces anapyrexia in adult humans in association with decreased peripheral oxygen saturation (SpO). Ten healthy male subjects were seated in atmospheres of normobaric normoxia 21% (NN21), NH 17% (NH17), and 13% (NH13) O for 60 minutes in a counterbalanced manner. Rectal temperature (Tre) was continuously monitored together with the quantification of metabolic heat production (MHP) and body heat storage (S). Baseline physiological measurements showed no differences between the three conditions. SpO was significantly decreased in NH17 and NH13 compared with NN21 (p ≤ 0.001). Tre decreased following 60 minutes of resting in all conditions, but, independent of the conditions, showed no association between Tre and levels of hypoxic SpO. There was also no significant difference in either MHP or S between conditions. The present results showed no evidence of hypoxia-induced anapyrexia in adult humans during 1 hour of resting after exposure to NH either at 13% or 17% O.
徐英硕、海登·D·格哈特、杰里迈亚·沃恩、金贞贤和埃伦·L·利克曼。急性常压缺氧会导致成年人体温过低吗？《高海拔医学与生物学》。2017年第18卷：第185 - 190页。——已知暴露于缺氧环境会导致核心体温降低，这是一种保护机制，在动物和人类身上均已得到证实。本研究的目的是测试急性暴露于常压缺氧（NH）是否会导致成年人体温过低，并伴有外周血氧饱和度（SpO）降低。10名健康男性受试者以平衡的方式分别在常压常氧21%（NN21）、NH 17%（NH17）和13%（NH13）氧气环境中坐60分钟。连续监测直肠温度（Tre），同时对代谢产热（MHP）和身体蓄热（S）进行量化。基线生理测量结果显示三种条件之间无差异。与NN21相比，NH17和NH13中的SpO显著降低（p≤0.001）。在所有条件下休息60分钟后Tre均下降，但与条件无关，Tre与低氧SpO水平之间无关联。各条件下MHP或S也无显著差异。目前的结果表明，在暴露于13%或17%氧气的NH后1小时休息期间，没有证据表明成年人体温过低是由缺氧引起的。
