Sadiq Faizan A, Flint Steve, Li Yun, Liu TongJie, Lei Yuan, Sakandar Hafiz Arbab, He GuoQing
a College of Biosystems Engineering and Food Science , Zhejiang University , Hangzhou , PR China.
b School of Food and Nutrition , Massey University , Palmerston North , New Zealand.
Biofouling. 2017 Apr;33(4):306-326. doi: 10.1080/08927014.2017.1304541. Epub 2017 Mar 28.
A biofilm is a complex assemblage of microbial communities adhered to a biotic or an abiotic surface which is embedded within a self-produced matrix of extracellular polymeric substances. Many transcriptional regulators play a role in triggering a motile-sessile switch and in consequently producing the biofilm matrix. This review is aimed at highlighting the role of two nucleotide signaling molecules (c-di-GMP and c-di-AMP), toxin antitoxin modules and a novel transcriptional regulator BolA in biofilm formation in various bacteria. In addition, it highlights the common themes that have appeared in recent research regarding the key regulatory components and signal transduction pathways that help Bacillus subtilis and Pseudomonas aeruginosa to acquire the biofilm mode of life.
生物膜是附着在生物或非生物表面的微生物群落的复杂聚集体，这些微生物群落嵌入在自身产生的细胞外聚合物基质中。许多转录调节因子在触发游动-固着转变以及随后产生生物膜基质方面发挥作用。本综述旨在强调两种核苷酸信号分子（环二鸟苷酸和环二腺苷酸）、毒素-抗毒素模块以及一种新型转录调节因子BolA在各种细菌生物膜形成中的作用。此外，还强调了近期研究中出现的关于帮助枯草芽孢杆菌和铜绿假单胞菌获得生物膜生活方式的关键调节成分和信号转导途径的共同主题。
