Quan Ming, Cui Jiu-Jie, Feng Xiao, Huang Qian
Cancer Center, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China.
Tumour Biol. 2017 Mar;39(3):1010428317694544. doi: 10.1177/1010428317694544.
Autotaxin, an ecto-lysophospholipase D encoded by the human ENNP2 gene, is expressed in multiple tissues, and participates in numerous critical physiologic and pathologic processes including inflammation, pain, obesity, embryo development, and cancer via the generation of the bioactive lipid lysophosphatidate. Overwhelming evidences indicate that the autotaxin/lysophosphatidate signaling axis serves key roles in the numerous processes central to tumorigenesis and progression, including proliferation, survival, migration, invasion, metastasis, cancer stem cell, tumor microenvironment, and treatment resistance by interacting with a series of at least six G-protein-coupled receptors (LPAR1-6). This review provides an overview of the autotaxin/lysophosphatidate axis and collates current knowledge regarding its specific role in pancreatic cancer. With a deeper understanding of the critical role of the autotaxin/lysophosphatidate axis in pancreatic cancer, targeting autotaxin or lysophosphatidate receptor may be a potential and promising strategy for cancer therapy.
自分泌运动因子是一种由人类ENNP2基因编码的胞外溶血磷脂酶D，在多种组织中表达，并通过生成生物活性脂质溶血磷脂酸参与众多关键的生理和病理过程，包括炎症、疼痛、肥胖、胚胎发育和癌症。大量证据表明，自分泌运动因子/溶血磷脂酸信号轴在肿瘤发生和进展的众多核心过程中发挥关键作用，包括增殖、存活、迁移、侵袭、转移、癌症干细胞、肿瘤微环境以及通过与一系列至少六种G蛋白偶联受体（LPAR1 - 6）相互作用产生的治疗抗性。本综述概述了自分泌运动因子/溶血磷脂酸轴，并整理了有关其在胰腺癌中具体作用的当前知识。随着对自分泌运动因子/溶血磷脂酸轴在胰腺癌中关键作用的更深入理解，靶向自分泌运动因子或溶血磷脂酸受体可能是一种潜在且有前景的癌症治疗策略。
