Centre for Public Health,Queen's University Belfast,Belfast,UK.
Institute of Biological Environmental and Rural Sciences,Aberystwyth University,Aberystwyth,Ceredigion,UK.
Proc Nutr Soc. 2017 Aug;76(3):308-315. doi: 10.1017/S0029665117000325. Epub 2017 Mar 28.
A high intake of fruit and vegetables (FV) has been associated with reduced risk of a number of chronic diseases, including CVD. The aim of this review is to describe the potential use of biomarkers to assess FV intake. Traditional methods of assessing FV intake have limitations, and this is likely to impact on observed associations with disease outcomes and markers of disease risk. Nutritional biomarkers may offer a more objective and reliable method of assessing dietary FV intake. Some single blood biomarkers, such as plasma vitamin C and serum carotenoids, are well established as indicators of FV intake. Combining potential biomarkers of intake may more accurately predict overall FV intake within intervention studies than the use of any single biomarker. Another promising approach is metabolomic analysis of biological fluids using untargeted approaches to identify potential new biomarkers of FV intake. Using biomarkers to measure FV intake may improve the accuracy of dietary assessment.
大量摄入水果和蔬菜（FV）与多种慢性疾病（包括心血管疾病）风险降低有关。本综述旨在描述使用生物标志物评估 FV 摄入量的潜在用途。评估 FV 摄入量的传统方法存在局限性，这可能会影响与疾病结局和疾病风险标志物的观察相关性。营养生物标志物可能提供一种更客观和可靠的方法来评估饮食中的 FV 摄入量。一些单一的血液生物标志物，如血浆维生素 C 和血清类胡萝卜素，已被很好地确立为 FV 摄入量的指标。在干预研究中，将潜在的摄入量生物标志物结合起来，可能比使用任何单一的生物标志物更能准确地预测总体 FV 摄入量。另一种很有前途的方法是使用非靶向方法对生物体液进行代谢组学分析，以确定 FV 摄入量的潜在新生物标志物。使用生物标志物来测量 FV 摄入量可以提高饮食评估的准确性。
