Deb Rachayeeta, Nagotu Shirisha
Organelle Biology and Cellular Ageing Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
Organelle Biology and Cellular Ageing Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
Tissue Cell. 2017 Apr;49(2 Pt B):209-226. doi: 10.1016/j.tice.2017.03.002. Epub 2017 Mar 7.
Research spanning almost 50 years has highlighted unique characteristics and irreplaceable list of diverse functions performed by peroxisomes in various model systems. Peroxisomes are single membrane bound highly dynamic organelles ubiquitous to most eukaryotic cells. Proliferation by division of pre-existing organelles and the role of endoplasmic reticulum in the biogenesis of these organelles is now well established. The earliest identified conserved functions of peroxisomes are β-oxidation of fatty acids and reactive oxygen species metabolism. Several studies over the last few decades have reported the importance of this organelle and its numerous cell type, tissue and environment-dependent functions. Their role in several aspects of human health and disease is now under investigation. Studies related to peroxisome biology and functions are now also extended to diverse model systems like Drosophila melanogaster, trypanosomatids, etc. Peroxisomes also intricately collaborate and carry out these functions together with several other organelles in a cell. In this review, we aim to present an overview of our current knowledge of the repertoire of functions of peroxisomes in various model systems.
近50年的研究突出了过氧化物酶体在各种模型系统中的独特特征和一系列不可替代的多样功能。过氧化物酶体是大多数真核细胞中普遍存在的单膜结合的高度动态细胞器。通过已有细胞器的分裂进行增殖以及内质网在这些细胞器生物发生中的作用现已得到充分证实。过氧化物酶体最早被确定的保守功能是脂肪酸的β-氧化和活性氧代谢。过去几十年的多项研究报道了这种细胞器的重要性及其众多依赖细胞类型、组织和环境的功能。它们在人类健康和疾病的多个方面的作用目前正在研究中。与过氧化物酶体生物学和功能相关的研究现在也扩展到了果蝇、锥虫等多种模型系统。过氧化物酶体还与细胞中的其他几种细胞器复杂地协作并共同执行这些功能。在这篇综述中，我们旨在概述我们目前对过氧化物酶体在各种模型系统中的功能库的认识。
