百里香精油的抗皮肤癣菌活性。

The anti-dermatophyte activity of Zataria multiflora essential oils.

作者信息

Mahboubi M, HeidaryTabar R, Mahdizadeh E

机构信息

Department of Microbiology, Medicinal Plants, Research Center of Barij, Kashan, Iran.

出版信息

J Mycol Med. 2017 Jun;27(2):232-237. doi: 10.1016/j.mycmed.2017.03.001. Epub 2017 Mar 24.

DOI:10.1016/j.mycmed.2017.03.001

PMID:28347599

Abstract

OBJECTIVE

Dermtophytes are a group of pathogenic fungi and the major cause of dermatophytosis in humans and animals. Fighting dermatophytes by natural essential oils is one important issue in new researches.

MATERIALS AND METHODS

In this investigation, we evaluated the anti-dermatophyte activities of three samples of Z. multiflora essential oils against dermatophytes along with analysis of chemical compositions of the essential oils and their anti-elastase activities on elastase production in dermatophytes.

RESULTS

Carvacrol (1.5-34.4%), thymol (25.8-41.2%), carvacrol methyl ether (1.9-28.3%) and p-cymene (2.3-8.3%) were the main components of Z. multiflora essential oils. Z. multiflora essential oils (100ppm) inhibited the mycelium growth of dermatophytes (6±1.7-47.0±1.4%) and had the minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) values of 0.03-0.25μl/ml against dermatophytes. Essential oils inhibited elastase produced in dermatophytes and pure porcine elastase.

CONCLUSION

Z. multiflora essential oils can be used as natural anti-dermatophyte agent for fighting dermatophytes in further preclinical and clinical studies.

摘要

目的

皮肤癣菌是一类致病真菌，是人和动物皮肤癣菌病的主要病因。利用天然香精油对抗皮肤癣菌是新研究中的一个重要课题。

材料与方法

在本研究中，我们评估了三种多花紫珠香精油样品对皮肤癣菌的抗皮肤癣菌活性，同时分析了香精油的化学成分及其对皮肤癣菌产生弹性蛋白酶的抗弹性蛋白酶活性。

结果

香芹酚（1.5 - 34.4%）、百里香酚（25.8 - 41.2%）、香芹酚甲醚（1.9 - 28.3%）和对伞花烃（2.3 - 8.3%）是多花紫珠香精油的主要成分。多花紫珠香精油（100ppm）抑制皮肤癣菌的菌丝生长（6±1.7 - 47.0±1.4%），对皮肤癣菌的最低抑菌浓度（MIC）和最低杀菌浓度（MFC）值为0.03 - 0.25μl/ml。香精油抑制皮肤癣菌产生的弹性蛋白酶和纯猪弹性蛋白酶。