代谢状态在发育和疾病中的作用。
The role of metabolic states in development and disease.
作者信息
Sieber Matthew H, Spradling Allan C
机构信息
Department of Embryology, Howard Hughes Medical Institute Labs, Carnegie Institution for Science, Baltimore, MD 21218, United States.
Department of Embryology, Howard Hughes Medical Institute Labs, Carnegie Institution for Science, Baltimore, MD 21218, United States.
出版信息
Curr Opin Genet Dev. 2017 Aug;45:58-68. doi: 10.1016/j.gde.2017.03.002. Epub 2017 Mar 24.
Abstract
During development, cells adopt distinct metabolic strategies to support growth, produce energy, and meet the demands of a mature tissue. Some of these metabolic states maintain a constrained program of nutrient utilization, while others providing metabolic flexibility as a means to couple developmental progression with nutrient availability. Here we discuss our understanding of metabolic programs, and how they support specific aspects of animal development. During phases of rapid proliferation a subset of metabolic programs provide the building blocks to support growth. During differentiation, metabolic programs shift to support the unique demands of each tissue. Finally, we discuss how a model system, such as Drosophila egg development, can provide a versatile platform to discover novel mechanisms controlling programmed shift in metabolism.
摘要
在发育过程中，细胞采用不同的代谢策略来支持生长、产生能量并满足成熟组织的需求。其中一些代谢状态维持着有限的营养利用程序，而其他代谢状态则提供代谢灵活性，作为将发育进程与营养可用性相耦合的一种手段。在这里，我们讨论我们对代谢程序的理解，以及它们如何支持动物发育的特定方面。在快速增殖阶段，一部分代谢程序提供支持生长的构建模块。在分化过程中，代谢程序发生转变以支持每个组织的独特需求。最后，我们讨论诸如果蝇卵子发育这样的模型系统如何能够提供一个通用平台，以发现控制代谢程序化转变的新机制。
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