• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Neutrophils diminish T-cell immunity to foster gastric cancer progression: the role of GM-CSF/PD-L1/PD-1 signalling pathway.

作者信息

Zhang Xu, Xu Wenrong

机构信息

Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.

出版信息

Gut. 2017 Nov;66(11):1878-1880. doi: 10.1136/gutjnl-2017-313923. Epub 2017 Mar 27.

DOI:10.1136/gutjnl-2017-313923
PMID:28348197
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5739856/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f134/5739856/491c7a75cdea/gutjnl-2017-313923f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f134/5739856/491c7a75cdea/gutjnl-2017-313923f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f134/5739856/491c7a75cdea/gutjnl-2017-313923f01.jpg

相似文献

1
Neutrophils diminish T-cell immunity to foster gastric cancer progression: the role of GM-CSF/PD-L1/PD-1 signalling pathway.中性粒细胞削弱T细胞免疫以促进胃癌进展:GM-CSF/PD-L1/PD-1信号通路的作用
Gut. 2017 Nov;66(11):1878-1880. doi: 10.1136/gutjnl-2017-313923. Epub 2017 Mar 27.
2
Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway.胃癌中肿瘤激活的中性粒细胞通过GM-CSF-PD-L1途径促进免疫抑制和疾病进展。
Gut. 2017 Nov;66(11):1900-1911. doi: 10.1136/gutjnl-2016-313075. Epub 2017 Mar 8.
3
PD-1/PD-L1 blockade enhances the efficacy of SA-GM-CSF surface-modified tumor vaccine in prostate cancer.PD-1/PD-L1 阻断增强了 SA-GM-CSF 表面修饰肿瘤疫苗在前列腺癌中的疗效。
Cancer Lett. 2017 Oct 10;406:27-35. doi: 10.1016/j.canlet.2017.07.029. Epub 2017 Aug 8.
4
Expression, regulation and clinical significance of B7-H3 on neutrophils in human gastric cancer.B7-H3 在人胃癌中性粒细胞中的表达、调控及临床意义。
Clin Immunol. 2021 Jun;227:108753. doi: 10.1016/j.clim.2021.108753. Epub 2021 May 1.
5
The influence of granulocyte macrophage colony-stimulating factor and prior chemotherapy on the immunological response to a vaccine (ALVAC-CEA B7.1) in patients with metastatic carcinoma.粒细胞巨噬细胞集落刺激因子和先前化疗对转移性癌患者疫苗(ALVAC-CEA B7.1)免疫反应的影响。
Clin Cancer Res. 2001 May;7(5):1181-91.
6
Expression of granulocyte colony stimulating factor (G-CSF) and granulocyte/macrophage colony stimulating factor (GM-CSF) mRNA upon stimulation with phorbol ester.佛波酯刺激后粒细胞集落刺激因子(G-CSF)和粒细胞/巨噬细胞集落刺激因子(GM-CSF)mRNA的表达
Blood Cells Mol Dis. 1995;21(3):192-200. doi: 10.1006/bcmd.1995.0022.
7
Chemotherapy induces tumor immune evasion by upregulation of programmed cell death ligand 1 expression in bone marrow stromal cells.化疗通过上调骨髓基质细胞中程序性细胞死亡配体 1 的表达诱导肿瘤免疫逃逸。
Mol Oncol. 2017 Apr;11(4):358-372. doi: 10.1002/1878-0261.12032. Epub 2017 Feb 20.
8
Induction of T-cell apoptosis in rats by genetically engineered glioma cells expressing granulocyte-macrophage colony-stimulating factor and B7.1.表达粒细胞巨噬细胞集落刺激因子和B7.1的基因工程化胶质瘤细胞诱导大鼠T细胞凋亡
Clin Cancer Res. 2005 Feb 15;11(4):1639-49. doi: 10.1158/1078-0432.CCR-04-1366.
9
Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know.粒细胞-巨噬细胞集落刺激因子(GM-CSF)与T细胞反应:我们所知道和不知道的
Cell Res. 2006 Feb;16(2):126-33. doi: 10.1038/sj.cr.7310017.
10
Decreased granulocyte-macrophage colony-stimulating factor production by human neonatal blood mononuclear cells and T cells.人新生儿血液单核细胞和T细胞产生的粒细胞巨噬细胞集落刺激因子减少。
Pediatr Res. 1992 Mar;31(3):211-6. doi: 10.1203/00006450-199203000-00004.

引用本文的文献

1
A high level of secreted phosphoprotein 1 is associated with macrophage infiltration and poor prognosis in hepatocellular carcinoma.高水平的分泌性磷蛋白1与肝细胞癌中的巨噬细胞浸润及不良预后相关。
ILIVER. 2023 Feb 19;2(1):26-35. doi: 10.1016/j.iliver.2023.01.004. eCollection 2023 Mar.
2
Neutrophils in cancer: At the crucial crossroads of anti-tumor and pro-tumor.癌症中的中性粒细胞:处于抗肿瘤与促肿瘤的关键十字路口。
Cancer Commun (Lond). 2025 Aug;45(8):888-913. doi: 10.1002/cac2.70027. Epub 2025 Apr 29.
3
The immunomodulatory ballet of tumour-derived extracellular vesicles and neutrophils orchestrating the dynamic CD73/PD-L1 pathway in cancer.

本文引用的文献

1
Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway.胃癌中肿瘤激活的中性粒细胞通过GM-CSF-PD-L1途径促进免疫抑制和疾病进展。
Gut. 2017 Nov;66(11):1900-1911. doi: 10.1136/gutjnl-2016-313075. Epub 2017 Mar 8.
2
Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer.具有抗原呈递细胞特征的肿瘤相关中性粒细胞亚群在早期人类肺癌中的起源及作用
Cancer Cell. 2016 Jul 11;30(1):120-135. doi: 10.1016/j.ccell.2016.06.001. Epub 2016 Jun 30.
3
Neutrophils in cancer: neutral no more.
肿瘤来源的细胞外囊泡与中性粒细胞共同调控肿瘤动态 CD73/PD-L1 通路的免疫调节之舞。
J Extracell Vesicles. 2024 Jul;13(7):e12480. doi: 10.1002/jev2.12480.
4
Gastric tubular adenocarcinoma with diffuse neutrophils infiltrating: characteristics and probable treatment strategy.弥漫中性粒细胞浸润的胃管状腺癌:特征及可能的治疗策略。
Gastric Cancer. 2024 Jan;27(1):86-101. doi: 10.1007/s10120-023-01446-6. Epub 2023 Nov 29.
5
A Prospective Study on the Roles of the Lymphocyte-to-Monocyte Ratio (LMR), Neutrophil-to-Lymphocyte Ratio (NLR), and Platelet-to-Lymphocyte Ratio (PLR) in Patients with Locally Advanced Rectal Cancer.淋巴细胞与单核细胞比值(LMR)、中性粒细胞与淋巴细胞比值(NLR)及血小板与淋巴细胞比值(PLR)在局部晚期直肠癌患者中作用的前瞻性研究
Biomedicines. 2023 Nov 14;11(11):3048. doi: 10.3390/biomedicines11113048.
6
Immune Evasion of G-CSF and GM-CSF in Lung Cancer.肺癌中粒细胞集落刺激因子和粒细胞-巨噬细胞集落刺激因子的免疫逃逸
Tuberc Respir Dis (Seoul). 2024 Jan;87(1):22-30. doi: 10.4046/trd.2023.0037. Epub 2023 Sep 20.
7
HER2-Positive Gastric Cancer: The Role of Immunotherapy and Novel Therapeutic Strategies.人表皮生长因子受体 2 阳性胃癌:免疫治疗及新型治疗策略的作用。
Int J Mol Sci. 2023 Jul 13;24(14):11403. doi: 10.3390/ijms241411403.
8
Crosstalk of Immune Cells and Platelets in an Ovarian Cancer Microenvironment and Their Prognostic Significance.免疫细胞与血小板在卵巢癌微环境中的相互作用及其预后意义。
Int J Mol Sci. 2023 May 25;24(11):9279. doi: 10.3390/ijms24119279.
9
Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers.间叶性胃肠道癌症的免疫学和免疫治疗进展。
Mol Cancer. 2023 Apr 18;22(1):71. doi: 10.1186/s12943-023-01770-6.
10
ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions.ERdj5 可保护杯状细胞免受炎症条件下内质网应激介导的细胞凋亡。
Exp Mol Med. 2023 Feb;55(2):401-412. doi: 10.1038/s12276-023-00945-x. Epub 2023 Feb 9.
肿瘤微环境中的中性粒细胞:不再中立。
Nat Rev Cancer. 2016 Jul;16(7):431-46. doi: 10.1038/nrc.2016.52. Epub 2016 Jun 10.
4
Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib.肿瘤相关中性粒细胞招募巨噬细胞和 T 调节细胞促进肝细胞癌进展和索拉非尼耐药。
Gastroenterology. 2016 Jun;150(7):1646-1658.e17. doi: 10.1053/j.gastro.2016.02.040. Epub 2016 Feb 26.
5
Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma.肿瘤周围中性粒细胞通过PD-L1/PD-1信号通路对肝细胞癌的适应性免疫产生负向调节作用。
J Exp Clin Cancer Res. 2015 Nov 18;34:141. doi: 10.1186/s13046-015-0256-0.
6
The wound inflammatory response exacerbates growth of pre-neoplastic cells and progression to cancer.伤口炎症反应会加剧癌前细胞的生长并促使其发展成癌症。
EMBO J. 2015 Sep 2;34(17):2219-36. doi: 10.15252/embj.201490147. Epub 2015 Jul 1.
7
Insights into Myeloid-Derived Suppressor Cells in Inflammatory Diseases.炎症性疾病中髓源性抑制细胞的研究进展
Arch Immunol Ther Exp (Warsz). 2015 Aug;63(4):269-85. doi: 10.1007/s00005-015-0342-1. Epub 2015 May 20.
8
IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis.产生白细胞介素-17的γδ T细胞和中性粒细胞共同促进乳腺癌转移。
Nature. 2015 Jun 18;522(7556):345-348. doi: 10.1038/nature14282. Epub 2015 Mar 30.
9
Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils.浸润性乳腺癌会重编程骨髓中早期髓系分化,以产生免疫抑制性中性粒细胞。
Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E566-75. doi: 10.1073/pnas.1424927112. Epub 2015 Jan 26.
10
Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer.癌症患者循环中性粒细胞亚群的表型多样性和可塑性。
Cell Rep. 2015 Feb 3;10(4):562-73. doi: 10.1016/j.celrep.2014.12.039. Epub 2015 Jan 22.