Potapenko R I
Ukr Biokhim Zh (1978). 1988 Jan-Feb;60(1):61-4.
The study of albino rats aged 6-7 months and 25-27 months revealed the age-related increase of maximal activity (V) of Na+, K+-ATPase of synaptosomal plasma membranes, separated from the cerebral cortex, while the level of Km remained stable. It is shown that in old rats as compared to the adult ones the affinity of Na+, K+-ATPase to sodium ions increases and the character of the ATP hydrolysis schedule changes in the presence of different ration of ions-activators. There are no significant changes in the inhibiting effect of strophantidin K on Na+, K+-ATPase activity of synaptosomal plasma membranes.
对6 - 7个月龄和25 - 27个月龄的白化大鼠的研究表明，从大脑皮层分离出的突触体细胞膜上的Na +，K + - ATP酶的最大活性（V）随年龄增长而增加，而Km水平保持稳定。结果表明，与成年大鼠相比，老年大鼠的Na +，K + - ATP酶对钠离子的亲和力增加，并且在存在不同比例的离子激活剂的情况下，ATP水解过程的特性发生变化。毒毛旋花子苷K对突触体细胞膜上Na +，K + - ATP酶活性的抑制作用没有显著变化。
