Lv Junhua, Liu Feng
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of SciencesBeijing, China; University of Chinese Academy of SciencesBeijing, China.
Front Cell Neurosci. 2017 Mar 13;11:74. doi: 10.3389/fncel.2017.00074. eCollection 2017.
Serotonin, or 5-hydroxytryptamine (5-HT), is a well-known neurotransmitter that plays vital roles in neural activities and social behaviors. Clinically, deficiency of serotonin is linked with many psychiatric disorders. Interestingly, a large proportion of serotonin is also produced outside the central nervous system (CNS). There is increasing evidence demonstrating important roles of serotonin in the peripheral tissues. Here, we will describe the multiple biological functions of serotonin in hematopoietic system, such as development of hematopoietic stem and progenitor cells (HSPCs), differentiation of hematopoietic cells, maintenance of vascular system, and relationship with hematological diseases. The roles of serotonin in inflammatory responses mediated by hematopoietic cells as well as in liver regeneration are also discussed. Our recent understandings of the impact of serotonin on hematopoietic system, immune responses, and tissue regeneration support utilization of serotonin as a potential therapeutic target for the treatment of hematological diseases and organ repair in clinic.
血清素，即5-羟色胺（5-HT），是一种著名的神经递质，在神经活动和社会行为中发挥着至关重要的作用。临床上，血清素缺乏与许多精神疾病有关。有趣的是，很大一部分血清素也在中枢神经系统（CNS）之外产生。越来越多的证据表明血清素在外周组织中具有重要作用。在此，我们将描述血清素在造血系统中的多种生物学功能，例如造血干细胞和祖细胞（HSPCs）的发育、造血细胞的分化、血管系统的维持以及与血液系统疾病的关系。还将讨论血清素在造血细胞介导的炎症反应以及肝脏再生中的作用。我们最近对血清素对造血系统、免疫反应和组织再生影响的理解支持将血清素作为治疗血液系统疾病和临床器官修复的潜在治疗靶点加以利用。
