Department of Basic Science, California Northstate University College of Medicine, Elk Grove, CA 95757, United States.
Department of Basic Science, California Northstate University College of Medicine, Elk Grove, CA 95757, United States.
Pharmacol Res. 2019 Feb;140:100-114. doi: 10.1016/j.phrs.2018.06.015. Epub 2018 Jun 25.
Serotonin (5-HT), a well-known neurotransmitter in the brain, also plays an important role in peripheral tissues, including the immune system. There is a growing body of evidence suggesting that many different types of immune cells express the machinery to generate, store, respond to and/or transport serotonin, including T cells, macrophages, mast cells, dendritic cells and platelets. In addition, there is emerging evidence of a possible connection between T cells, serotonin and mood disorders. How 5-HT interacts with the peripheral immune system and if this signaling is associated with behavioral phenotypes found in mood disorders like major depressive disorder (MDD) is not well understood. In this review, we summarize the existing literature on what is known about the link between 5-HT and the immune system and the effects of 5-HT signaling on different cells of the peripheral immune system, with a particular focus on T cells. In addition, we review the current evidence that peripheral immune system alterations and CNS function may be interrelated and the possible implications of these findings for drug discovery.
血清素（5-HT）是大脑中一种众所周知的神经递质，在包括免疫系统在内的外周组织中也发挥着重要作用。越来越多的证据表明，许多不同类型的免疫细胞都表达产生、储存、响应和/或运输血清素的机制，包括 T 细胞、巨噬细胞、肥大细胞、树突状细胞和血小板。此外，T 细胞、血清素和情绪障碍之间可能存在联系的证据也在不断涌现。5-HT 如何与外周免疫系统相互作用，以及这种信号是否与情绪障碍（如重度抑郁症（MDD））中发现的行为表型有关，目前还不是很清楚。在这篇综述中，我们总结了关于 5-HT 与免疫系统之间联系的现有文献，以及 5-HT 信号对外周免疫系统不同细胞的影响，特别关注 T 细胞。此外，我们还回顾了目前关于外周免疫系统改变和中枢神经系统功能可能相互关联的证据，以及这些发现对药物发现的可能影响。
