Thon W F, Sparwasser C, Gilbert P, Altwein J E
Abteilung Urologie, Bundeswehrkrankenhaus Ulm.
Urol Int. 1987;42(6):445-9. doi: 10.1159/000282013.
Since the initiation of a 'surveillance' therapy the role of retroperitoneal lymph node dissection as standard treatment in the management of patients with clinical stage I nonseminomatous germ cell testicular tumor (NSGCTT) continues to be debated. Noninvasive staging techniques (CT scans, lymphography, ultrasound and serologic tumor markers) help to identify more accurately patients with distant metastases. 'Surveillance' alone as a possible treatment modality following orchidectomy in selected patients with clinical stage I NSGCTT requires cooperative and reliable patients. In our urological clinic surveillance alone is not justified any longer because of a noncompliance rate of 10% and a relapse rate of 30%, although the early detection of small-volume metastatic disease, lymphadenectomy and polychemotherapy result in a high rate of cure. Any patient should be excluded from 'wait and see' protocols if metastatic prognostic factors such as vascular infiltration of the primary tumor or local tumor stage greater than pT1 are identified.
自从启动“监测”疗法以来,对于临床I期非精原细胞性生殖细胞睾丸肿瘤(NSGCTT)患者,腹膜后淋巴结清扫术作为标准治疗方法的作用一直存在争议。非侵入性分期技术(CT扫描、淋巴造影、超声和血清学肿瘤标志物)有助于更准确地识别远处转移患者。对于部分临床I期NSGCTT患者,单纯“监测”作为睾丸切除术后一种可能的治疗方式,需要患者配合且可靠。在我们的泌尿外科诊所,由于不依从率为10%,复发率为30%,单纯监测已不再合理,尽管早期发现小体积转移性疾病、淋巴结切除术和多药化疗可带来较高的治愈率。如果发现转移预后因素,如原发肿瘤血管浸润或局部肿瘤分期大于pT1,任何患者都应排除在“观察等待”方案之外。