Ribeiro Rodrigo, Melo Rayanne, Tortamano Neto Pedro, Vajgel André, Souza Paulo Roberto Eleutério, Cimões Renata
Federal University of Campina Grande, Campina Grande, PB, Brazil.
Federal University of Pernambuco, Recife, PE, Brazil.
Int J Dent. 2017;2017:3901368. doi: 10.1155/2017/3901368. Epub 2017 Feb 28.
. Genetic polymorphisms in certain cytokines and chemokines have been investigated to understand why some individuals display implant flaws despite having few risk factors at the time of implant. . To investigate the association of genetic polymorphisms in interleukin- [-1082 region (A/G)] and [-438 region (A/G)] with the failure of dental implants. . This study included 90 partially edentulous male and female patients who were rehabilitated with a total of 245 Straumann dental implants. An implant was considered a failure if any of the following occurred: mobility, persistent subjective complaint, recurrent peri-implant infection with suppuration, continuous radiolucency around the implant, probing depth ≥ 5 mm, and bleeding on probing. Buccal mucosal cells were collected for analysis of and . . The implant success rate in this population was 34.4%. The mutant allele (G) in had an incidence of 52.3% and mutant allele (A) in was observed in 37.8%. No statistically significant difference was detected between the failure of the implant and the genotypes and allelic frequencies. . No association was detected between the genetic polymorphisms of (-438) and (-1082) and the failure of dental implants in the population studied.
已对某些细胞因子和趋化因子中的基因多态性进行了研究，以了解为何有些个体尽管在植入时风险因素较少，但仍出现植入缺陷。为了研究白细胞介素-（-1082区域（A/G））和-（-438区域（A/G））中的基因多态性与牙种植体失败之间的关联。本研究纳入了90例部分牙列缺损的男性和女性患者，他们总共植入了245颗士卓曼牙种植体。如果出现以下任何一种情况，则认为种植体失败：松动、持续的主观不适、反复的种植体周围感染伴化脓、种植体周围持续的透射区、探诊深度≥5毫米以及探诊出血。采集颊黏膜细胞用于分析和。该人群中的种植体成功率为34.4%。中突变等位基因（G）的发生率为52.3%，中突变等位基因（A）的观察发生率为37.8%。在种植体失败与基因型和等位基因频率之间未检测到统计学上的显著差异。在所研究的人群中，未检测到（-438）和（-1082）的基因多态性与牙种植体失败之间存在关联。
