Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants.

. Genetic polymorphisms in certain cytokines and chemokines have been investigated to understand why some individuals display implant flaws despite having few risk factors at the time of implant. . To investigate the association of genetic polymorphisms in interleukin- [-1082 region (A/G)] and [-438 region (A/G)] with the failure of dental implants. . This study included 90 partially edentulous male and female patients who were rehabilitated with a total of 245 Straumann dental implants. An implant was considered a failure if any of the following occurred: mobility, persistent subjective complaint, recurrent peri-implant infection with suppuration, continuous radiolucency around the implant, probing depth ≥ 5 mm, and bleeding on probing. Buccal mucosal cells were collected for analysis of and . . The implant success rate in this population was 34.4%. The mutant allele (G) in had an incidence of 52.3% and mutant allele (A) in was observed in 37.8%. No statistically significant difference was detected between the failure of the implant and the genotypes and allelic frequencies. . No association was detected between the genetic polymorphisms of (-438) and (-1082) and the failure of dental implants in the population studied.