Heimbach Esther J, Bowden Rodney G, Griggs Jackson O, Beaujean A Alexander, Doyle Eva I, Doyle Robert D
Baylor University, Waco, Texas, USA.
Family Health Center, Waco, Texas, USA.
Cardiol Res. 2012 Apr;3(2):80-86. doi: 10.4021/cr168w. Epub 2012 Mar 20.
Researchers have reported an independent direct relationship between lipid levels and hyperuricemia with MetS. The purpose of this study was to determine the relationship between serum uric acid levels and lipids among patients on allopurinol.
A retrospective secondary data analysis was conducted on 66 adult patients from a family health clinic in Central Texas. Medical records used were recorded during a nine year period (2002 - 2010) ascertaining the relationship between uric acid and lipids.
Spearman correlations revealed a weak correlation between uric acid and total cholesterol, a weak correlation between uric acid and triglycerides and LDL-C. A weak inverse correlation was discovered between uric acid and HDL-C. A moderate correlation was discovered when all lipid variables combined were compared to uric acid.
We discovered LDL-C and triglycerides to be significant predictors of uric acid with weak correlations. Additionally, weak correlations existed between uric acid and total cholesterol and HDL-C with an inverse relationship discovered with HDL-C. These findings support the literature suggesting that uric acid is more likely to be associated with total cholesterol and triglycerides. In addition, new discoveries serve as an indication that LDL-C may also be associated with uric acids levels. The mechanism by which uric acid may regulate lipids is elusive but suggestions have included suppression of lipid peroxidase and decreases in critical lipase activity.
研究人员报告了脂质水平与伴有代谢综合征的高尿酸血症之间存在独立的直接关系。本研究的目的是确定接受别嘌醇治疗的患者血清尿酸水平与脂质之间的关系。
对来自德克萨斯州中部一家家庭健康诊所的66名成年患者进行回顾性二次数据分析。所使用的医疗记录是在九年期间（2002 - 2010年）记录的，以确定尿酸与脂质之间的关系。
Spearman相关性分析显示尿酸与总胆固醇之间存在弱相关性，尿酸与甘油三酯及低密度脂蛋白胆固醇之间存在弱相关性。发现尿酸与高密度脂蛋白胆固醇之间存在弱负相关性。当将所有脂质变量组合与尿酸进行比较时，发现存在中度相关性。
我们发现低密度脂蛋白胆固醇和甘油三酯是尿酸的显著预测因子，但相关性较弱。此外，尿酸与总胆固醇和高密度脂蛋白胆固醇之间存在弱相关性，其中与高密度脂蛋白胆固醇呈负相关。这些发现支持了文献中的观点，即尿酸更可能与总胆固醇和甘油三酯相关。此外，新的发现表明低密度脂蛋白胆固醇也可能与尿酸水平相关。尿酸调节脂质的机制尚不清楚，但有观点认为可能包括抑制脂质过氧化物酶和降低关键脂肪酶活性。
