Kaneko Masanori, Oda Eiji, Kayamori Hiromi, Nagao Satomi, Watanabe Hiroshi, Abe Takahiro, Ishizawa Masahiro, Uemura Yasuyuki, Aizawa Yoshifusa
Department of Internal Medicine, Tachikawa Medical Center, Kanda 3-2-11, Nagaoka, Niigata, Japan.
Medical Check-up Center, Tachikawa Medical Center, Nagachou 2-2-16, Nagaoka, Niigata, Japan.
Cardiol Res. 2012 Apr;3(2):87-93. doi: 10.4021/cr95w. Epub 2012 Mar 20.
The association between cigarette smoking and hypertension is controversial. The aim of this study is to investigate the association between smoking and incident hypertension.
This is a post-hoc five-year follow-up study in a general Japanese population. Logistic regressions were performed using incident hypertension as an outcome and smoking status as an independent predictor adjusting for sex, age, body mass index (BMI), total cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, fasting plasma glucose (FPG), drinking status, and diabetes in 1,297 subjects without hypertension at baseline.
The incidence of hypertension was 16.9% vs. 27.6% (smokers vs. nonsmokers, P = 0.01) in men and 0.0% vs. 16.9% (smokers vs. nonsmokers, P = 0.03) in women. The odds ratio (OR) (95% confidence interval (CI)) of incident hypertension was 0.38 (0.19 - 0.76) (P = 0.006) for smokers at baseline, 0.33 (0.16 - 0.68) (P = 0.003) for continuing smokers, and 2.11 (0.33 - 13.45) (P = 0.4) for ex-smokers. Age (OR = 1.52, P < 0.0001), BMI (OR = 1.46, P < 0.0001), and FPG (OR = 1.23, P = 0.007) were other independent predictors of incident hypertension.
Smoking was a possible significant negative predictor of incident hypertension in a general Japanese population.
吸烟与高血压之间的关联存在争议。本研究旨在调查吸烟与高血压发病之间的关联。
这是一项针对日本普通人群的事后五年随访研究。以高血压发病作为结局，吸烟状况作为独立预测因素，对1297名基线时无高血压的受试者进行逻辑回归分析，并对性别、年龄、体重指数（BMI）、总胆固醇、高密度脂蛋白（HDL）胆固醇、甘油三酯、空腹血糖（FPG）、饮酒状况和糖尿病进行校正。
男性高血压发病率吸烟者为16.9%，非吸烟者为27.6%（P = 0.01）；女性吸烟者为0.0%，非吸烟者为16.9%（P = 0.03）。基线时吸烟者发生高血压的比值比（OR）（95%置信区间（CI））为0.38（0.19 - 0.76）（P = 0.006），持续吸烟者为0.33（0.16 - 0.68）（P = 0.003），戒烟者为2.11（0.33 - 13.45）（P = 0.4）。年龄（OR = 1.52，P < 0.0001）、BMI（OR = 1.46，P < 0.0001）和FPG（OR = 1.23，P = 0.007）是高血压发病的其他独立预测因素。
在日本普通人群中，吸烟可能是高血压发病的一个重要负性预测因素。
