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2013年颈动脉支架置入术:值得肯定。

Carotid Artery Stenting 2013: Thumbs up.

作者信息

Wagdi Philipp

机构信息

Interventional Cardiology, HerzZentrum Hirslanden, Witellikerstrasse 36, 8008 Zurich, Switzerland. Email:

出版信息

Cardiol Res. 2013 Feb;4(1):8-14. doi: 10.4021/cr253w. Epub 2013 Mar 8.

Abstract

It has been customary for interventional cardiologists involved in carotid artery stenting, to underline non-inferiority of the percutaneous technique versus surgical carotid endarterectomy. To that end, all cause morbidity and mortality figures of both methods are compared. Surgery has, in most large randomized studies, had an edge over stenting in terms of cerebrovascular adverse events. This may have partly been due to occasional indiscriminate indication for stenting in lesions and/or vessels with unfavourable characteristics (severe target vessel tortuosity and calcification, Type III aortic arch, and so on). On one hand, the author pleads for improvement of the excellent results of endarterectomy, by subjecting all patients planned for surgery to a thorough preoperative cardiological work up, including generous invasive investigation, thus reducing the incidence of perioperative myocardial infarction, heart failure and cardiac death. On the other hand, we are convinced that the results of carotid stenting should then be compared to best practice surgery. The rate of neurological adverse event rate after carotid endarterectomy at our institution lies under 0.7% at 30 days postoperatively. Specifically, the goal should be that carotid stenting underbids surgical endarterectomy, also and mainly, in terms of cerebral and cerebrovascular adverse events. Cardiac morbidity and mortality as well as laryngeal nerve palsy should no more be the main arguments for the percutaneous approach. This should easily be possible if patient selection for carotid revascularisation would be approached according to morphological criteria, in analogy with the "Syntax"-score used to optimise revascularisation strategies in coronary artery disease.

摘要

参与颈动脉支架置入术的介入心脏病学家习惯强调经皮技术相对于外科颈动脉内膜切除术的非劣效性。为此,会比较两种方法的全因发病率和死亡率数据。在大多数大型随机研究中,就脑血管不良事件而言,外科手术比支架置入术更具优势。这可能部分归因于在病变和/或具有不利特征(严重的靶血管迂曲和钙化、III型主动脉弓等)的血管中偶尔进行的支架置入术的指征不明确。一方面,作者主张通过对所有计划进行手术的患者进行全面的术前心脏检查,包括大量的侵入性检查,来改善内膜切除术的优异结果,从而降低围手术期心肌梗死、心力衰竭和心源性死亡的发生率。另一方面,我们坚信,届时应将颈动脉支架置入术的结果与最佳手术实践进行比较。我们机构颈动脉内膜切除术后30天的神经不良事件发生率低于0.7%。具体而言,目标应该是,在脑和脑血管不良事件方面,颈动脉支架置入术也要而且主要是要优于外科内膜切除术。心脏发病率和死亡率以及喉返神经麻痹不应再成为经皮治疗方法的主要论据。如果根据形态学标准选择颈动脉血运重建患者,类似于用于优化冠状动脉疾病血运重建策略的“Syntax”评分,这应该很容易实现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b2/5358182/f6e3d3659f23/cr-04-008-g001.jpg

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