2型糖尿病与胰腺癌风险增加相关：一项退伍军人管理局登记研究。
Type 2 diabetes mellitus is associated with increased risk of pancreatic cancer: A veteran administration registry study.
作者信息
Makhoul Issam, Yacoub Abdulraheem, Siegel Eric
机构信息
Hematology/Oncology Division, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Division of Hematology/Oncology, The University of Kansas Medical Center, Kansas City, KS, USA.
出版信息
SAGE Open Med. 2016 Dec 14;4:2050312116682257. doi: 10.1177/2050312116682257. eCollection 2016.
BACKGROUND
The etiology of pancreatic cancer remains elusive. Several studies have suggested a role for diabetes mellitus, but the magnitude of its contribution remains controversial.
OBJECTIVES
Utilizing a large administrative database, this retrospective cohort study was designed to investigate the relationship between type 2 diabetes mellitus and pancreatic cancer.
PATIENTS AND DESIGN
Using the Veterans Integrated Services Network 16 database, 322,614 subjects were enrolled in the study, including 110,919 with type 2 diabetes mellitus and 211,695 diabetes-free controls matched by gender, year of birth and healthcare facility.
RESULTS
A significantly higher incidence of pancreatic cancer was observed in patients with type 2 diabetes mellitus, with an adjusted hazard ratio (95% confidence interval) of 2.17 (1.70-2.77) for type 2 diabetes mellitus compared to controls (p < 10) after controlling for the matching factors.
CONCLUSION
The association between type 2 diabetes mellitus and pancreatic cancer was statistically significant and may, in part, explain the rising incidence of pancreatic cancer.
背景
胰腺癌的病因仍不明确。多项研究表明糖尿病可能与之相关，但其作用程度仍存在争议。
目的
本回顾性队列研究利用大型管理数据库，旨在探讨2型糖尿病与胰腺癌之间的关系。
患者与研究设计
使用退伍军人综合服务网络16数据库，共有322,614名受试者纳入研究，其中包括110,919名2型糖尿病患者以及211,695名无糖尿病的对照者，后者在性别、出生年份和医疗机构方面与病例组相匹配。
结果
2型糖尿病患者中胰腺癌的发病率显著更高，在控制匹配因素后，2型糖尿病患者与对照组相比，校正风险比（95%置信区间）为2.17（1.70 - 2.77）（p < 0.001）。
结论
2型糖尿病与胰腺癌之间的关联具有统计学意义，这可能部分解释了胰腺癌发病率上升的原因。
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