Wang Ye-Tao, Gou Ya-Wen, Jin Wen-Wen, Xiao Mei, Fang Hua-Ying
Department of gastroenterology, Anhui provincial hospital, NO.17, Lujiang Road, Hefei City, Anhui Province, 230001, China.
BMC Cancer. 2016 Mar 12;16:212. doi: 10.1186/s12885-016-2241-1.
Studies examining the association between alcohol intake and the risk of pancreatic cancer have given inconsistent results. The purpose of this study was to summarize and examine the evidence regarding the association between alcohol intake and pancreatic cancer risk based on results from prospective cohort studies.
We searched electronic databases consisting of PubMed, Ovid, Embase, and the Cochrane Library identifying studies published up to Aug 2015. Only prospective studies that reported effect estimates with 95% confidence intervals (CIs) for the risk of pancreatic cancer, examining different alcohol intake categories compared with a low alcohol intake category were included. Results of individual studies were pooled using a random-effects model.
We included 19 prospective studies (21 cohorts) reporting data from 4,211,129 individuals. Low-to-moderate alcohol intake had little or no effect on the risk of pancreatic cancer. High alcohol intake was associated with an increased risk of pancreatic cancer (risk ratio [RR], 1.15; 95% CI: 1.06-1.25). Pooled analysis also showed that high liquor intake was associated with an increased risk of pancreatic cancer (RR, 1.43; 95% CI: 1.17-1.74). Subgroup analyses suggested that high alcohol intake was associated with an increased risk of pancreatic cancer in North America, when the duration of follow-up was greater than 10 years, in studies scored as high quality, and in studies with adjustments for smoking status, body mass index, diabetes mellitus, and energy intake..
Low-to-moderate alcohol intake was not significantly associated with the risk of pancreatic cancer, whereas high alcohol intake was associated with an increased risk of pancreatic cancer. Furthermore, liquor intake in particular was associated with an increased risk of pancreatic cancer.
关于酒精摄入量与胰腺癌风险之间关联的研究结果并不一致。本研究的目的是根据前瞻性队列研究的结果，总结并审视有关酒精摄入量与胰腺癌风险之间关联的证据。
我们检索了包括PubMed、Ovid、Embase和Cochrane图书馆在内的电子数据库，以识别截至2015年8月发表的研究。仅纳入那些报告了胰腺癌风险效应估计值及95%置信区间（CI）的前瞻性研究，这些研究比较了不同酒精摄入量类别与低酒精摄入量类别。使用随机效应模型汇总个体研究的结果。
我们纳入了19项前瞻性研究（21个队列），报告了来自4,211,129人的数据。低至中度酒精摄入对胰腺癌风险几乎没有影响或没有影响。高酒精摄入与胰腺癌风险增加相关（风险比[RR]，1.15；95%CI：1.06 - 1.25）。汇总分析还表明，高白酒摄入与胰腺癌风险增加相关（RR，1.43；95%CI：1.17 - 1.74）。亚组分析表明，在北美，当随访时间超过10年时，在高质量评分的研究中，以及在对吸烟状况、体重指数、糖尿病和能量摄入进行调整的研究中，高酒精摄入与胰腺癌风险增加相关。
低至中度酒精摄入与胰腺癌风险无显著关联，而高酒精摄入与胰腺癌风险增加相关。此外，特别是白酒摄入与胰腺癌风险增加相关。
