Kwok T'ng Choong, Poyner Jennifer, Olson Ewan, Henriksen Peter, Koch Oliver
Edinburgh Heart Centre, Western General Hospital , Edinburgh , Scotland.
Clinical Microbiology, Royal Infirmary Edinburgh , Edinburgh , Scotland.
JMM Case Rep. 2016 Oct 27;3(5):e005065. doi: 10.1099/jmmcr.0.005065. eCollection 2016 Oct.
is a rare cause of infective endocarditis. Here, we report a case involving the native mitral valve in the absence of an implantable cardiac electronic device.
A 76-year-old man presented with a 2 week history of confusion and pyrexia. His past medical history included an open reduction and internal fixation of a humeral fracture 17 years previously, which remained non-united despite further revision 4 years later. There was no history of immunocompromise or farm-animal contact. Two sets of blood culture bottles, more than 12 h apart, were positive for . Trans-thoracic echocardiography revealed a 1×1.2 cm vegetation on the mitral valve, with moderate mitral regurgitation. Due to ongoing confusion, he had a magnetic resonance imaging brain scan, which showed a subacute small vessel infarct consistent with a thromboembolic source. A humeral SPECT-CT (single-photon emission computerized tomography-computerized tomography) scan showed no clear evidence of acute osteomyelitis. Surgical vegetectomy and mitral-valve repair were considered to reduce the risk of further systemic embolism and progressive valve infection. However, the potential risks of surgery to this patient led to a decision to pursue a cure with antibiotic therapy alone. He remained well 3 months after discharge, with repeat echocardiography demonstrating a reduction in the size of the vegetation (0.9 cm).
Management of this infection was challenging due to its rarity and its unclear progression, complicated by the dilemma surrounding surgical intervention in a patient with a complex medical background.
是感染性心内膜炎的罕见病因。在此,我们报告一例累及天然二尖瓣且无植入式心脏电子设备的病例。
一名76岁男性,有2周的意识模糊和发热病史。他既往病史包括17年前肱骨骨折的切开复位内固定术,尽管4年后再次翻修,但骨折仍未愈合。无免疫功能低下或接触农场动物的病史。两套间隔超过12小时采集的血培养瓶培养出阳性。经胸超声心动图显示二尖瓣上有一个1×1.2厘米的赘生物,伴有中度二尖瓣反流。由于持续意识模糊,他进行了脑部磁共振成像扫描,结果显示有一个亚急性小血管梗死灶,符合血栓栓塞源。肱骨单光子发射计算机断层扫描 - 计算机断层扫描(SPECT - CT)扫描未显示急性骨髓炎的明确证据。考虑进行手术切除赘生物和二尖瓣修复以降低进一步发生全身栓塞和瓣膜进行性感染的风险。然而,该患者手术的潜在风险导致决定仅采用抗生素治疗来治愈疾病。出院3个月后他情况良好,复查超声心动图显示赘生物大小缩小(0.9厘米)。
由于这种感染罕见且病情进展不明确,再加上该患者有复杂的病史,围绕手术干预存在两难困境,因此对这种感染的管理具有挑战性。