Cardiology Division, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Radiology Department, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Sci Rep. 2017 Mar 28;7:45314. doi: 10.1038/srep45314.
The cine magnetic resonance imaging based technique feature tracking-cardiac magnetic resonance (FT-CMR) is emerging as a novel, simple and robust method to evaluate myocardial strain. We investigated the distribution characteristics of left-ventricular myocardial strain using a novel cine MRI based deformation registration algorithm (DRA) in a cohort of healthy Chinese subjects. A total of 130 healthy Chinese subjects were enrolled. Three components of orthogonal strain (radial, circumferential, longitudinal) of the left ventricle were analyzed using DRA on steady-state free precession cine sequence images. A distinct transmural circumferential strain gradient was observed in the left ventricle that showed universal increment from the epicardial to endocardial myocardial wall (epiwall: -15.4 ± 1.9%; midwall: -18.8 ± 2.0%; endowall: -22.3 ± 2.3%, P < 0.001). Longitudinal strain showed a similar trend from epicardial to endocardial layers (epiwall: -16.0 ± 2.9%; midwall: -15.6 ± 2.7%; endowall: -14.8 ± 2.4%, P < 0.001), but radial strain had a very heterogeneous distribution and variation. In the longitudinal direction from the base to the apex of the left ventricle, there was a trend of decreasing peak systolic longitudinal strain (basal: -23.3 ± 4.6%; mid: -13.7 ± 7.3%; apical: -13.2 ± 5.5%; P < 0.001). In conclusion, there are distinct distribution patterns of circumferential and longitudinal strain within the left ventricle in healthy Chinese subjects. These distribution patterns of strain may provide unique profiles for further study in different types of myocardial disease.
电影磁共振成像为基础的技术特征跟踪心脏磁共振（FT-CMR）正在成为一种新颖、简单和强大的方法来评估心肌应变。我们使用一种新的电影 MRI 基于变形配准算法（DRA）研究了左心室心肌应变的分布特征，在一组健康的中国受试者中。总共纳入了 130 名健康的中国受试者。使用 DRA 在稳态自由进动电影序列图像上分析了左心室的三个正交应变分量（径向、圆周、纵向）。左心室心肌存在明显的圆周向应变梯度，从心外膜到心内膜心肌壁呈普遍递增（心外膜：-15.4 ± 1.9%；中层：-18.8 ± 2.0%；心内膜：-22.3 ± 2.3%，P < 0.001）。纵向应变从心外膜到心内膜层也呈现出相似的趋势（心外膜：-16.0 ± 2.9%；中层：-15.6 ± 2.7%；心内膜：-14.8 ± 2.4%，P < 0.001），但径向应变分布不均匀且变化较大。从左心室基底到心尖的纵向方向上，收缩期纵向应变峰值呈下降趋势（基底：-23.3 ± 4.6%；中层：-13.7 ± 7.3%；心尖：-13.2 ± 5.5%；P < 0.001）。总之，在健康的中国受试者中，左心室存在明显的圆周向和纵向应变分布模式。这些应变分布模式可能为不同类型的心肌疾病提供独特的特征。
