Zhu Yu-Ning, Fan Wen-Jing, Zhang Chi, Guo Fang, Li Wei, Wang Yu-Fei, Jiang Zhi-Sheng, Qu Shun-Lin
Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, P.R. China.
Mol Med Rep. 2017 May;15(5):2903-2908. doi: 10.3892/mmr.2017.6403. Epub 2017 Mar 28.
Atherosclerosis (AS) remains the leading cause for global cardiovascular disease morbidity and mortality, and a major cause of cardiopathy, myocardial infarction and peripheral vascular diseases. Macrophages serve a critical role in atherosclerotic plaque stabilization and rupture, and the selective removal of macrophages may be beneficial in improving plaque stability. Autophagy is a process of self‑feeding, during which cytoplasmic proteins or organelles are packaged into vesicles and fused with the lysosome to form an autophagosome. The newly formed autophagosome can degrade internalized proteins, and this process may be used to serve the metabolic and self‑renewal requirements of the cell. Autophagy serves an important role in maintaining cell homeostasis and promoting cell survival, and therefore an imbalance in autophagy is closely associated with multiple diseases.
动脉粥样硬化（AS）仍然是全球心血管疾病发病和死亡的主要原因，也是心脏病、心肌梗死和外周血管疾病的主要病因。巨噬细胞在动脉粥样硬化斑块的稳定和破裂中起关键作用，选择性清除巨噬细胞可能有助于改善斑块稳定性。自噬是一个自我吞噬的过程，在此过程中，细胞质蛋白或细胞器被包裹在囊泡中并与溶酶体融合形成自噬体。新形成的自噬体可以降解内化的蛋白质，这一过程可用于满足细胞的代谢和自我更新需求。自噬在维持细胞稳态和促进细胞存活中起重要作用，因此自噬失衡与多种疾病密切相关。
