• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

mTOR mediates the cross-talk of macrophage polarization and autophagy in atherosclerosis.

作者信息

Tian Feng, Yu Bi-lian, Hu Jia-rui

机构信息

Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China.

Department of Spine Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China; Department of Cardiothoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China.

出版信息

Int J Cardiol. 2014 Nov 15;177(1):144-5. doi: 10.1016/j.ijcard.2014.09.035. Epub 2014 Sep 23.

DOI:10.1016/j.ijcard.2014.09.035
PMID:25499362
Abstract
摘要

相似文献

1
mTOR mediates the cross-talk of macrophage polarization and autophagy in atherosclerosis.雷帕霉素靶蛋白（mTOR）介导动脉粥样硬化中巨噬细胞极化与自噬的相互作用。
Int J Cardiol. 2014 Nov 15;177(1):144-5. doi: 10.1016/j.ijcard.2014.09.035. Epub 2014 Sep 23.
2
Response to Feng Tian et al.: mTOR mediates the cross-talk of macrophage polarization and autophagy in atherosclerosis.
Int J Cardiol. 2015 Apr 1;184:262. doi: 10.1016/j.ijcard.2015.02.057. Epub 2015 Feb 24.
3
Knockdown of mTOR by lentivirus‑mediated RNA interference suppresses atherosclerosis and stabilizes plaques via a decrease of macrophages by autophagy in apolipoprotein E‑deficient mice.慢病毒介导的 RNA 干扰敲低 mTOR 通过自噬减少巨噬细胞来抑制载脂蛋白 E 缺陷小鼠的动脉粥样硬化并稳定斑块。
Int J Mol Med. 2013 Nov;32(5):1215-21. doi: 10.3892/ijmm.2013.1494. Epub 2013 Sep 12.
4
Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance.巨噬细胞在动脉粥样硬化和肥胖诱导的胰岛素抵抗中有益功能的新证据。
J Mol Med (Berl). 2016 Mar;94(3):267-75. doi: 10.1007/s00109-016-1385-4. Epub 2016 Feb 4.
5
Role of autophagy in advanced atherosclerosis (Review).自噬在晚期动脉粥样硬化中的作用（综述）
Mol Med Rep. 2017 May;15(5):2903-2908. doi: 10.3892/mmr.2017.6403. Epub 2017 Mar 28.
6
The roles of macrophage autophagy in atherosclerosis.巨噬细胞自噬在动脉粥样硬化中的作用。
Acta Pharmacol Sin. 2016 Feb;37(2):150-6. doi: 10.1038/aps.2015.87. Epub 2016 Jan 11.
7
Self-eating in the plaque: what macrophage autophagy reveals about atherosclerosis.斑块中的自噬：巨噬细胞自噬对动脉粥样硬化的启示。
Trends Endocrinol Metab. 2014 May;25(5):225-34. doi: 10.1016/j.tem.2014.03.010. Epub 2014 Apr 17.
8
Carrier-Free Trehalose-Based Nanomotors Targeting Macrophages in Inflammatory Plaque for Treatment of Atherosclerosis.用于治疗动脉粥样硬化的、靶向炎症斑块中巨噬细胞的无载体海藻糖基纳米马达
ACS Nano. 2022 Mar 22;16(3):3808-3820. doi: 10.1021/acsnano.1c08391. Epub 2022 Feb 24.
9
mTOR trains heightened macrophage responses.mTOR 训练增强巨噬细胞反应。
Trends Immunol. 2015 Jan;36(1):1-2. doi: 10.1016/j.it.2014.11.004. Epub 2014 Dec 2.
10
IL-27 inhibits IFN-γ induced autophagy by concomitant induction of JAK/PI3 K/Akt/mTOR cascade and up-regulation of Mcl-1 in Mycobacterium tuberculosis H37Rv infected macrophages.白细胞介素-27通过在结核分枝杆菌H37Rv感染的巨噬细胞中同时诱导JAK/PI3K/Akt/mTOR级联反应和上调Mcl-1来抑制干扰素-γ诱导的自噬。
Int J Biochem Cell Biol. 2014 Oct;55:335-47. doi: 10.1016/j.biocel.2014.08.022. Epub 2014 Sep 4.

引用本文的文献

1
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy.三七皂苷R1和柴胡皂苷B2在动脉粥样硬化中的协同作用：一种靶向PI3K/AKT/mTOR通路和巨噬细胞自噬的新方法。
PLoS One. 2025 Jun 27;20(6):e0326687. doi: 10.1371/journal.pone.0326687. eCollection 2025.
2
High glucose promotes macrophage switching to the M1 phenotype via the downregulation of STAT-3 mediated autophagy.高糖通过下调STAT-3介导的自噬促进巨噬细胞向M1表型转变。
PLoS One. 2024 Dec 31;19(12):e0314974. doi: 10.1371/journal.pone.0314974. eCollection 2024.
3
Elucidating the crosstalk between endothelial-to-mesenchymal transition (EndoMT) and endothelial autophagy in the pathogenesis of atherosclerosis.
阐明动脉粥样硬化发病机制中内皮细胞向间充质转化（EndoMT）与内皮细胞自噬之间的串扰。
Vascul Pharmacol. 2024 Jun;155:107368. doi: 10.1016/j.vph.2024.107368. Epub 2024 Mar 26.
4
Characterization of changes in the intestinal microbiome following combination therapy with zinc preparation and conventional treatment for children with rotavirus enteritis.轮状病毒肠炎患儿联合锌制剂与常规治疗后肠道微生物组变化的特征。
Front Cell Infect Microbiol. 2023 Sep 29;13:1153701. doi: 10.3389/fcimb.2023.1153701. eCollection 2023.
5
miRNA-29a inhibits atherosclerotic plaque formation by mediating macrophage autophagy via PI3K/AKT/mTOR pathway.miRNA-29a 通过 PI3K/AKT/mTOR 通路介导巨噬细胞自噬抑制动脉粥样硬化斑块形成。
Aging (Albany NY). 2022 Mar 14;14(5):2418-2431. doi: 10.18632/aging.203951.
6
Role of lysosomes in physiological activities, diseases, and therapy.溶酶体在生理活动、疾病和治疗中的作用。
J Hematol Oncol. 2021 May 14;14(1):79. doi: 10.1186/s13045-021-01087-1.
7
Role of autophagy in atherosclerosis: foe or friend?自噬在动脉粥样硬化中的作用：敌还是友？
J Inflamm (Lond). 2019 May 2;16:8. doi: 10.1186/s12950-019-0212-4. eCollection 2019.
8
A role for autophagy in carotid atherosclerosis.自噬在颈动脉粥样硬化中的作用。
Eur Stroke J. 2016 Dec;1(4):255-263. doi: 10.1177/2396987316674085. Epub 2016 Oct 12.
9
Rapamycin and FTY720 Alleviate Atherosclerosis by Cross Talk of Macrophage Polarization and Autophagy.雷帕霉素和 FTY720 通过巨噬细胞极化和自噬的交叉对话减轻动脉粥样硬化。
Biomed Res Int. 2018 Dec 6;2018:1010248. doi: 10.1155/2018/1010248. eCollection 2018.
10
Aerobic Exercise Prevents Insulin Resistance Through the Regulation of miR-492/Resistin Axis in Aortic Endothelium.有氧运动通过调节主动脉内皮细胞 miR-492/Resistin 轴预防胰岛素抵抗。
J Cardiovasc Transl Res. 2018 Dec;11(6):450-458. doi: 10.1007/s12265-018-9828-7. Epub 2018 Sep 19.