Hachitanda Y, Tsuneyoshi M, Daimaru Y, Enjoji M, Nakagawara A, Ikeda K, Sueishi K
Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Cancer. 1988 Jun 15;61(12):2521-6. doi: 10.1002/1097-0142(19880615)61:12<2521::aid-cncr2820611222>3.0.co;2-r.
Two extraskeletal myxoid chondrosarcomas with a solid soft tissue mass occurred on the right upper arm of a 4-year-old boy and on the chest wall of a 1-year-old boy. Microscopically, both tumors were characterized by lobular configuration and were sparsely cellular with a background of myxoid matrix. The cells were small and round, and appeared undifferentiated, sometimes with a narrow eosinophilic cytoplasm. They grew in nests or strands and sometimes in a single file. They were strongly positive for S-100 protein and vimentin. Ultrastructural features suggested that the cells had a poorly differentiated mesenchymal nature with chondrocytic differentiation. These are the sixth and seventh reported cases of extraskeletal myxoid chondrosarcoma occurring in children. There are definite differences between this tumor with immature features and the extraskeletal myxoid chondrosarcoma in adults. Problems of differential diagnoses from other small round cell sarcomas also are discussed.
两例骨外黏液样软骨肉瘤分别发生于一名4岁男孩的右上臂和一名1岁男孩的胸壁，均为实性软组织肿块。显微镜下，这两个肿瘤均具有小叶状结构，细胞稀疏，伴有黏液样基质背景。细胞小而圆，呈未分化状态，有时有狭窄的嗜酸性细胞质。它们呈巢状或条索状生长，有时呈单行排列。它们对S-100蛋白和波形蛋白呈强阳性。超微结构特征表明这些细胞具有分化不良的间充质性质并伴有软骨细胞分化。这是报告的第六例和第七例发生于儿童的骨外黏液样软骨肉瘤。这种具有未成熟特征的肿瘤与成人骨外黏液样软骨肉瘤之间存在明显差异。本文还讨论了与其他小圆细胞肉瘤的鉴别诊断问题。
