Dardick I, Lgacé R, Carlier M T, Jung R C
Virchows Arch A Pathol Anat Histopathol. 1983;399(1):61-78. doi: 10.1007/BF00666219.
Evaluation of a series of 12 chordoid sarcomas suggests that there is a wider range of histological features in this entity then previously appreciated. Six of the lesions had a typical tumor cell organization and a mixture of cellular and myxoid stromal components, while the remaining cases were atypical because of a more solid growth pattern. Four of the 12 cases, that included both typically myxoid and more cellular examples, had small foci with hyalinized stroma segragating individual or small groups of tumor cells with and without lacunar spaces. Two atypical cases revealed more extensive and obvious chondrocytic differentiation in recurrent or metastatic lesions and in one of these, the histological pattern was that of mesenchymal chondrosarcoma. Ultrastructural examination of three cases revealed fine structural features of both the tumor cell population and extracellular matrix compatible with chondrocytic differentiation. Results of light and electron microscopy of this series of chordoid sarcoma add further support for categorizing this tumor with other malignant chondrocytic neoplasms. It is probable that chordoid sarcoma and extraskeletal myxoid chondrosarcoma represent the same entity and that this lesion has a close histogenetic relationship to mesenchymal chondrosarcoma.
对一系列12例脊索样肉瘤的评估表明，该实体的组织学特征范围比之前认识的更广。其中6例病变具有典型的肿瘤细胞结构以及细胞性和黏液样基质成分的混合，而其余病例则因生长模式更实性而不典型。12例病例中的4例，包括典型的黏液样和细胞性更强的病例，有小灶性玻璃样变的基质，将单个或小群肿瘤细胞分隔开，有或无腔隙。2例不典型病例在复发或转移病变中显示出更广泛且明显的软骨细胞分化，其中1例的组织学模式为间叶性软骨肉瘤。对3例病例的超微结构检查揭示了肿瘤细胞群体和细胞外基质的精细结构特征，与软骨细胞分化相符。这一系列脊索样肉瘤的光镜和电镜结果进一步支持将该肿瘤与其他恶性软骨细胞性肿瘤归为一类。脊索样肉瘤和骨外黏液样软骨肉瘤很可能代表同一实体，且该病变与间叶性软骨肉瘤有密切的组织发生学关系。
