Clinical Neuroscience Lab, Institute of Psychology, Polish Academy of Science, Warsaw, Poland.
Faculty of Psychology, University of Warsaw, Warsaw, Poland.
Sci Rep. 2017 Mar 28;7(1):484. doi: 10.1038/s41598-017-00565-2.
Social cognition deficits are observed both in patients with schizophrenia (SCZ) and in patients with mesial temporal lobe epilepsy (MTLE). This may be due to dysfunction of the amygdala network, which is a common feature of both diseases. In this study, SCZ (n = 48) or MTLE (n = 31) and healthy controls (HC, n = 47) completed assessments of mentalising (Reading Mind in the Eyes Test, RMET) and basic cognitive processing, e.g., working memory, executive functions and psychomotor speed (Trail-Making Test B and Digit Symbol). SCZ were also assessed with the Positive And Negative Syndrome Scale (PANSS). We found that the RMET scores of the two clinical groups were similar (p > 0.05) and lower than in the HCs (SCZ: p < 0.05; MTLE: p < 0.001). In the next step, SCZ were split into two groups with respect to the level of symptoms. Analysis of the RMET scores revealed no differences between the HC (M = 25.7 ± 4.1) and POS-LO (M = 25.3 ± 4.8); both groups outperformed the POS-HI group (M = 21.3 ± 5.2) and the MTLE group (M = 20.8 ± 4.6). No differences were found for the median-split with regard to negative symptoms. In SCZ, the mind-reading deficit appears to be associated with the level of positive symptoms. Both POS-HI and MTLE patients present significant mentalising deficits compared to healthy controls.
社会认知缺陷在精神分裂症（SCZ）患者和内侧颞叶癫痫（MTLE）患者中均有观察到。这可能是由于杏仁核网络功能障碍所致，这是两种疾病的共同特征。在这项研究中，SCZ（n = 48）或 MTLE（n = 31）和健康对照组（HC，n = 47）完成了心理化评估（读心测试，RMET）和基本认知处理，例如工作记忆、执行功能和运动速度（TMT-B 和数字符号）。SCZ 还接受了阳性和阴性症状量表（PANSS）的评估。我们发现，两个临床组的 RMET 分数相似（p > 0.05），且低于 HC（SCZ：p < 0.05；MTLE：p < 0.001）。在下一步中，根据症状水平将 SCZ 分为两组。RMET 评分分析显示，HC（M = 25.7 ± 4.1）和 POS-LO 组（M = 25.3 ± 4.8）之间没有差异；两组均优于 POS-HI 组（M = 21.3 ± 5.2）和 MTLE 组（M = 20.8 ± 4.6）。对于中位数的分割，阴性症状没有差异。在 SCZ 中，读心缺陷似乎与阳性症状的水平有关。POS-HI 和 MTLE 患者与健康对照组相比，均存在明显的心理化缺陷。
