Ayesa-Arriola Rosa, Setién-Suero Esther, Neergaard Karl D, Ferro Adele, Fatjó-Vilas Mar, Ríos-Lago Marcos, Otero Soraya, Rodríguez-Sánchez Jose M, Crespo-Facorro Benedicto
Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of CantabriaSantander, Spain; Centro Investigación Biomédica en Red de Salud Mental (CIBERSAM)Madrid, Spain.
Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria Santander, Spain.
Front Psychol. 2016 May 4;7:592. doi: 10.3389/fpsyg.2016.00592. eCollection 2016.
This study aimed to confirm whether first-episode psychosis patients present a stable trait impairment in theory of mind (ToM) and to examine the potential relationship between ToM and clinical symptomatology and neurocognition. Patients with a first episode of psychosis (N = 160) and healthy controls (N = 159) were assessed with an extensive neuropsychological test battery, which included a mental state decoding task known as "The Reading the Mind in the Eyes" (Eyes test), at baseline and reassessed after 1 and 3 years. The clinical group performed below healthy controls on the Eyes test while not showing test-retest differences between baseline and follow-up administrations. Analyses revealed age, education and premorbid IQ as potential moderators. Poorer performance on the Eyes test was not linked to clinical symptomatology but was associated with greater neurocognitive deficit, particularly related to processing speed. The persistence of ToM deficits in patients suggests that there are trait related metalizing impairments in first episode psychosis. This study shows the influence of processing speed and moderator variables on efficient ToM.
本研究旨在确认首发精神病患者在心理理论（ToM）方面是否存在稳定的特质损伤，并探讨ToM与临床症状及神经认知之间的潜在关系。对160例首发精神病患者和159例健康对照者在基线时进行了广泛的神经心理测试，其中包括一项名为“眼神读心术”（眼神测试）的心理状态解码任务，并在1年和3年后进行重新评估。临床组在眼神测试中的表现低于健康对照组，且在基线和随访测试之间未显示出重测差异。分析显示年龄、教育程度和病前智商为潜在调节因素。眼神测试中较差的表现与临床症状无关，但与更大的神经认知缺陷相关，尤其是与处理速度有关。患者中ToM缺陷的持续存在表明首发精神病存在与特质相关的心理化损伤。本研究显示了处理速度和调节变量对有效ToM的影响。
