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人类X染色体上G6PD基因座的表达与DNA 100 kb范围内三个CpG岛的去甲基化有关。

Expression of the G6PD locus on the human X chromosome is associated with demethylation of three CpG islands within 100 kb of DNA.

作者信息

Toniolo D, Martini G, Migeon B R, Dono R

机构信息

Istituto Internazionale di Genetica e Biofisica, CNR, Naples, Italy.

出版信息

EMBO J. 1988 Feb;7(2):401-6. doi: 10.1002/j.1460-2075.1988.tb02827.x.

DOI:10.1002/j.1460-2075.1988.tb02827.x
PMID:2835227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC454334/
Abstract

We have previously reported that expression of the G6PD locus is correlated with the methylation status of two islands of CpG dinucleotides which are 3' to the locus and in the 5' region of two adjacent genes of unknown function, P3 and GdX. We have now examined the methylation of a third CpG island in the promoter region of the G6PD gene itself in DNA from males, females and reactivants that express G6PD on the inactive X chromosome. Our results show that expression of the G6PD gene is associated with concordant demethylation of all three CpG islands in this 100-kb region of DNA.

摘要

我们之前报道过，葡萄糖-6-磷酸脱氢酶（G6PD）基因座的表达与两个CpG二核苷酸岛的甲基化状态相关，这两个岛位于该基因座的3'端以及两个功能未知的相邻基因P3和GdX的5'区域。我们现在检测了来自男性、女性以及在失活X染色体上表达G6PD的再活化细胞的DNA中，G6PD基因自身启动子区域的第三个CpG岛的甲基化情况。我们的结果表明，G6PD基因的表达与该100 kb DNA区域内所有三个CpG岛的协同去甲基化相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa7/454334/9b48394471b5/emboj00139-0110-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa7/454334/6b2233e6bdba/emboj00139-0108-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa7/454334/65b73004c5dc/emboj00139-0108-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa7/454334/36f04cabcc95/emboj00139-0109-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa7/454334/9b48394471b5/emboj00139-0110-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa7/454334/6b2233e6bdba/emboj00139-0108-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa7/454334/65b73004c5dc/emboj00139-0108-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa7/454334/36f04cabcc95/emboj00139-0109-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa7/454334/9b48394471b5/emboj00139-0110-a.jpg

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1
Expression of the G6PD locus on the human X chromosome is associated with demethylation of three CpG islands within 100 kb of DNA.人类X染色体上G6PD基因座的表达与DNA 100 kb范围内三个CpG岛的去甲基化有关。
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Complete concordance between glucose-6-phosphate dehydrogenase activity and hypomethylation of 3' CpG clusters: implications for X chromosome dosage compensation.葡萄糖-6-磷酸脱氢酶活性与3' CpG簇低甲基化之间的完全一致性：对X染色体剂量补偿的影响。
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Derepression with decreased expression of the G6PD locus on the inactive X chromosome in normal human cells.正常人类细胞中失活X染色体上G6PD基因座表达降低导致去抑制。
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Asynchronous DNA replication between 15q11.2q12 homologs: cytogenetic evidence for maternal imprinting and delayed replication.15号染色体长臂1区1带2亚带到1区2带同源染色体间的异步DNA复制：母源印记和延迟复制的细胞遗传学证据
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Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation.人类X染色体上次黄嘌呤磷酸核糖基转移酶基因座的甲基化：对X染色体失活的影响
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Complete concordance between glucose-6-phosphate dehydrogenase activity and hypomethylation of 3' CpG clusters: implications for X chromosome dosage compensation.葡萄糖-6-磷酸脱氢酶活性与3' CpG簇低甲基化之间的完全一致性：对X染色体剂量补偿的影响。
Nucleic Acids Res. 1984 Dec 21;12(24):9333-48. doi: 10.1093/nar/12.24.9333.
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Mammalian X-chromosome inactivation.哺乳动物X染色体失活。
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Transformation with DNA from 5-azacytidine-reactivated X chromosomes.用来自5-氮杂胞苷重新激活的X染色体的DNA进行转化。
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Specific methylation pattern at the 3' end of the human housekeeping gene for glucose 6-phosphate dehydrogenase.葡萄糖-6-磷酸脱氢酶的人类管家基因3'端的特定甲基化模式。
EMBO J. 1984 Sep;3(9):1987-95. doi: 10.1002/j.1460-2075.1984.tb02080.x.