Tomizawa Minoru, Shinozaki Fuminobu, Uchida Yoshitaka, Uchiyama Katsuhiro, Fugo Kazunori, Sunaoshi Takafumi, Ozaki Aika, Sugiyama Eriko, Baba Akira, Kano Daisuke, Shite Misaki, Haga Ryota, Fukamizu Yoshiya, Kagayama Satoshi, Hasegawa Rumiko, Shirai Yoshinori, Motoyoshi Yasufumi, Sugiyama Takao, Yamamoto Shigenori, Kishimoto Takashi, Ishige Naoki
Department of Gastroenterology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
Department of Radiology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
Exp Ther Med. 2017 Feb;13(2):639-644. doi: 10.3892/etm.2016.3981. Epub 2016 Dec 16.
Diffusion-weighted whole-body imaging with background body signal suppression/T2 image fusion (DWIBS/T2) is useful for the diagnosis of cancer as it presents a clear contrast between cancerous and non-cancerous tissue. The present study investigated the limitations and advantages of DWIBS/T2 with regards to the diagnosis of colorectal polyp (CP) or cancer (CRC). The current study included patients diagnosed with CP or CRC following colonoscopy, who were subjected to DWIBS/T2 between July 2012 and March 2015. Patient records were analyzed retrospectively. Patients were subjected to DWIBS/T2 when they presented with abdominal cancers or inflammation. Colonoscopy was performed as part of screening, or if patients had suspected colon cancer or inflammatory bowel disease. A total of 8 male and 7 female patients were enrolled in the present study. All patients, with the exception of one who had been diagnosed with CRC following colonoscopy, had positive results and all patients diagnosed with CP following a colonoscopy, with the exception of one, had negative results on DWIBS/T2. Thus, CRC was detected by DWIBS/T2, while CP was not (P=0.0028). The diameter of CRC lesions was significantly larger than that of CP (P<0.0001) and that of lesions positive on DWIBS/T2 was significantly larger than that of negative lesions (P=0.0004). The depth of invasion tended to be greater for lesions positive on DWIBS/T2 compared with that of negative ones. This indicated that DWIBS/T2 may be suitable for the detection of CRC but not for detection of CP. The results of DWIBS/T2 may also be affected by lesion diameter and depth of invasion.
背景体部信号抑制/ T2图像融合的扩散加权全身成像（DWIBS/T2）对癌症诊断很有用，因为它能在癌组织和非癌组织之间呈现出清晰的对比度。本研究调查了DWIBS/T2在诊断大肠息肉（CP）或癌症（CRC）方面的局限性和优势。本研究纳入了在2012年7月至2015年3月期间接受DWIBS/T2检查、经结肠镜检查诊断为CP或CRC的患者。对患者记录进行回顾性分析。当患者出现腹部癌症或炎症时，对其进行DWIBS/T2检查。结肠镜检查作为筛查的一部分进行，或者当患者疑似患有结肠癌或炎症性肠病时进行。本研究共纳入8例男性和7例女性患者。除1例经结肠镜检查诊断为CRC的患者外，所有患者检查结果均为阳性；除1例经结肠镜检查诊断为CP的患者外，所有诊断为CP的患者DWIBS/T2检查结果均为阴性。因此，DWIBS/T2可检测出CRC，而不能检测出CP（P=0.0028）。CRC病变的直径明显大于CP（P<0.0001），DWIBS/T2检查阳性病变的直径明显大于阴性病变（P=0.0004）。与阴性病变相比，DWIBS/T2检查阳性病变的浸润深度往往更大。这表明DWIBS/T2可能适用于CRC的检测，但不适用于CP的检测。DWIBS/T2的检查结果也可能受病变直径和浸润深度的影响。
