小生境星形胶质细胞促进大鼠缺血性中风后共移植神经干细胞的存活、增殖和神经元分化。
Niche astrocytes promote the survival, proliferation and neuronal differentiation of co-transplanted neural stem cells following ischemic stroke in rats.
作者信息
Luo Li, Guo Kaihua, Fan Wenguo, Lu Yinghong, Chen Lizhi, Wang Yang, Shao Yijia, Wu Gongxiong, Xu Jie, Lü Lanhai
机构信息
Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology and Institute of Stomatological Research, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, P.R. China; Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China; Department of Anatomy, School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China.
Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.
出版信息
Exp Ther Med. 2017 Feb;13(2):645-650. doi: 10.3892/etm.2016.4016. Epub 2016 Dec 30.
Niche astrocytes have been reported to promote neuronal differentiation through juxtacrine signaling. However, the effects of astrocytes on neuronal differentiation following ischemic stroke are not fully understood. In the present study, transplanted astrocytes and neural stem cells (NSCs) were transplanted into the ischemic striatum of transient middle cerebral artery occlusion (MCAO) model rats 48 h following surgery. It was observed that the co-transplantation of astrocytes and NSCs resulted in a higher ratio of survival and proliferation of the transplanted NSCs, and neuronal differentiation, in MCAO rats compared with NSC transplantation alone. These results demonstrate that the co-administration of astrocytes promotes the survival and neuronal differentiation of NSCs in the ischemic brain. These results suggest that the co-transplantation of astrocytes and NSCs is more effective than NSCs alone in the production of neurons following ischemic stroke in rats.
据报道，小生境星形胶质细胞通过旁分泌信号促进神经元分化。然而，星形胶质细胞对缺血性中风后神经元分化的影响尚未完全明确。在本研究中，于手术48小时后将移植的星形胶质细胞和神经干细胞（NSCs）移植到短暂性大脑中动脉闭塞（MCAO）模型大鼠的缺血纹状体中。观察到，与单独移植NSCs相比，星形胶质细胞和NSCs共同移植使MCAO大鼠中移植的NSCs存活和增殖比例更高，且神经元分化程度更高。这些结果表明，星形胶质细胞的共同给药可促进缺血脑中NSCs的存活和神经元分化。这些结果提示，在大鼠缺血性中风后产生神经元方面，星形胶质细胞和NSCs共同移植比单独移植NSCs更有效。
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