Žurek Jiří, Kýr Michal, Vavřina Martin, Fedora Michal
University Children's Hospital, Department of Anesthesia and Intensive Care, Černopolní 9, Brno, 62500, Czech Republic, telephone number: +420 53223 4695, fax: +420 53223 4252.
Faculty of Medicine, Masaryk University, Černopolní 9, Brno, 62500, Czech Republic.
Open Med (Wars). 2015 Apr 24;10(1):261-266. doi: 10.1515/med-2015-0020. eCollection 2015.
Gastrointestinal dysfunction or gut failure frequently occurs in seriously ill patients and can be responsible for multi-organ failure. Trefoil factor 3 (TFF3) was characterized for its role in reconstitution of an epithelial barrier after mucosal injury in the jejunum. The aims of our study was an analysis of TFF3 levels dynamics in patients with sepsis and the correlation of TFF3 with severity of sepsis and mortality.
Prospective observational study, a ten days evaluation period in children aged 0-19 years with systemic inflammatory response syndrome or septic state. Blood tests to determine levels of TFF3 were obtained as long as the patient met the criteria for systemic inflammatory response syndrome or sepsis.
Analysis of dynamics revealed steady levels of TFF3 during the 10 day period evaluated. TFF3 levels could not differentiate between various septic conditions in patients until a marked organ dysfunction developed. Higher Area Under Curve was noticed between control group and patients with sepsis. We could not make any strong conclusions based on mortality model.
Levels of TFF3 are elevated in paediatric patients with sepsis through organ dysfunction.
胃肠道功能障碍或肠衰竭在重症患者中经常发生，可能导致多器官功能衰竭。三叶因子3（TFF3）因其在空肠黏膜损伤后上皮屏障重建中的作用而被表征。我们研究的目的是分析脓毒症患者中TFF3水平的动态变化以及TFF3与脓毒症严重程度和死亡率的相关性。
前瞻性观察研究，对0至19岁患有全身炎症反应综合征或脓毒症状态的儿童进行为期10天的评估期。只要患者符合全身炎症反应综合征或脓毒症的标准，就进行血液检测以确定TFF3水平。
动态分析显示，在评估的10天期间，TFF3水平稳定。在明显的器官功能障碍出现之前，TFF3水平无法区分患者的各种脓毒症情况。对照组和脓毒症患者之间的曲线下面积较高。基于死亡率模型，我们无法得出任何有力的结论。
脓毒症小儿患者的TFF3水平通过器官功能障碍而升高。
