Qin Jian, Zhu Jianzhong, Zhang Yue, Li Changqin
, Division of Radiology, Taishan Medical School Affiliated Hospital, Taian, Shandong Province 271000, China.
Open Med (Wars). 2016 Mar 10;11(1):52-58. doi: 10.1515/med-2016-0011. eCollection 2016.
To investigate the magnetic diffusion weighted imaging (DWI) sequence and Spondyloarthritis Research Consortium of Canada (SPARCC) scoring in assessing curative effect of combined treatment of Chinese and Western medicine for early ankylosing spondylitis (AS).
48 cases diagnosed as early AS and treated with Chinese and Western medicine were included in the study. Magnetic routine and DWI sequence scanning image were performed to obtain the mean apparent diffusion coefficient (ADC) value of sub-articular surface bone marrow. Combined with SPARCC scoring, statistical analysis was conducted to compare the difference with the information obtained in the previous study.
The mean ADC value in the sub-articular surface bone marrow of patients after clinical treatment: (4.34±0.55)×10-4mm2/s in ilium and (3.96±0.23)×10-4mm2/s in sacrum, which were both significantly lower than that before treatment (p< 0.05). There was highly positive correlation between mean ADC value and SPARCC scoring (P<0.05). The regression relationship could be demonstrated as Y=-64.420+21.262X(Y: SPARCC scoring value; X: mean ADC value).
Magnetic DWI and SPARCC scoring could be applied in accessing AS inflammation activity changes and in reflect of curative effect of early AS patients as well as in providing reliable radiologist evidence for clinical therapeutic efficacy.
探讨磁共振扩散加权成像（DWI）序列及加拿大脊柱关节炎研究联盟（SPARCC）评分在评估中西医结合治疗早期强直性脊柱炎（AS）疗效中的应用。
纳入48例确诊为早期AS且接受中西医结合治疗的患者。行磁共振常规及DWI序列扫描成像，获取关节面下骨髓的平均表观扩散系数（ADC）值。结合SPARCC评分进行统计分析，与前期研究所得信息比较差异。
临床治疗后患者关节面下骨髓平均ADC值：髂骨为（4.34±0.55）×10⁻⁴mm²/s，骶骨为（3.96±0.23）×10⁻⁴mm²/s，均显著低于治疗前（p<0.05）。平均ADC值与SPARCC评分呈高度正相关（P<0.05）。回归关系可表示为Y=-64.420+21.262X（Y：SPARCC评分值；X：平均ADC值）。
磁共振DWI及SPARCC评分可用于评估AS炎症活动度变化，反映早期AS患者的疗效，为临床治疗效果提供可靠的影像学依据。
