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细胞毒性T淋巴细胞相关抗原4（CTLA-4）基因rs221775A>G单核苷酸多态性与多发性硬化易感性的相关性：一项荟萃分析

Correlation between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility. A meta-analysis.

作者信息

Haibing Xiao, Xu Cao, Jifu Cai, Wenshuang Zeng, Ling Li, Yuzhen Cui, Yanjun Hu

机构信息

Neurology, Internal Medicine, The University of Hong Kong-Shenzhen Hospital, Futian District, Shenzhen, Guangdong, PR China.

Department of Neurology, Shenzhen People's Hospital, Jinan University, Luohu District, Shenzhen, Guangdong, PR China.

出版信息

Open Med (Wars). 2016 Jul 22;11(1):264-269. doi: 10.1515/med-2016-0052. eCollection 2016.

DOI:10.1515/med-2016-0052
PMID:28352806
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5329839/
Abstract

OBJECTIVE

The aim of this meta-analysis was to undertake a meta-analysis to evaluate the correlation between cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene rs221775 A>G single nucleotide polymorphism and the susceptibility of multiple sclerosis (MS) susceptibility.

METHOD

Published manuscripts about CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility were searched in the computerized bibliographic searches of Pubmed Embase and China National Knowledge Infrastructure (CNKI). Potential studies were screened and data for 5025 MS patients and 4706 controls from 20 publications were included. The association between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility were demonstrated by odds ratio (OR) and 95% confidence interval (95%CI).

RESULTS

The pooled results showed no significant association between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility for dominant genetic model [OR=1.02, 95%CI:0.901.05, (P=0.80)], homozygous genetic model [OR=0.85,95%CI:0.71 ~1.03,(P=0.10)] and recessive genetic model [OR=0.99,95% CI:0.891.10,(P=0.90)].

CONCLUSION

With current evidence, CTLA-4 gene rs221775A>G single nucleotide polymorphism had no association with the susceptibility of multiple sclerosis.

摘要

目的

本荟萃分析旨在进行一项荟萃分析，以评估细胞毒性T淋巴细胞相关蛋白4（CTLA-4）基因rs221775 A>G单核苷酸多态性与多发性硬化症（MS）易感性之间的相关性。

方法

在PubMed、Embase和中国知网（CNKI）的计算机化文献检索中搜索关于CTLA-4基因rs221775A>G单核苷酸多态性与多发性硬化症易感性的已发表手稿。筛选潜在研究，并纳入来自20篇出版物的5025例MS患者和4706例对照的数据。通过比值比（OR）和95%置信区间（95%CI）来证明CTLA-4基因rs221775A>G单核苷酸多态性与多发性硬化症易感性之间的关联。

结果

汇总结果显示，在显性遗传模型[OR=1.02，95%CI：0.901.05，（P=0.80）]、纯合子遗传模型[OR=0.85，95%CI：0.711.03，（P=0.10）]和隐性遗传模型[OR=0.99，95%CI：0.89~1.10，（P=0.90）]下，CTLA-4基因rs2217-75A>G单核苷酸多态性与多发性硬化症易感性之间无显著关联。

结论

根据目前的证据，CTLA-4基因rs221775A>G单核苷酸多态性与多发性硬化症易感性无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/5329839/1b412d0b8c68/j_med-2016-0052_fig_006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/5329839/86d159d14ae2/j_med-2016-0052_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/5329839/e35599b671c0/j_med-2016-0052_fig_002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/5329839/5f65ff82a607/j_med-2016-0052_fig_003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/5329839/ac803cd298df/j_med-2016-0052_fig_004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/5329839/6730d7e9b7d6/j_med-2016-0052_fig_005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/5329839/1b412d0b8c68/j_med-2016-0052_fig_006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/5329839/86d159d14ae2/j_med-2016-0052_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/5329839/e35599b671c0/j_med-2016-0052_fig_002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/5329839/5f65ff82a607/j_med-2016-0052_fig_003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/5329839/ac803cd298df/j_med-2016-0052_fig_004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/5329839/6730d7e9b7d6/j_med-2016-0052_fig_005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/5329839/1b412d0b8c68/j_med-2016-0052_fig_006.jpg

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本文引用的文献

1
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2
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Int J Immunogenet. 2011 Oct;38(5):419-26. doi: 10.1111/j.1744-313X.2011.01027.x. Epub 2011 Jul 29.
3
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Front Immunol. 2023 Jul 11;14:1198365. doi: 10.3389/fimmu.2023.1198365. eCollection 2023.
4
The Role of Cytotoxic T-Lymphocyte Antigen 4 in the Pathogenesis of Multiple Sclerosis.细胞毒性 T 淋巴细胞相关抗原 4 在多发性硬化症发病机制中的作用。
Genes (Basel). 2022 Jul 24;13(8):1319. doi: 10.3390/genes13081319.
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Acta Neurol Scand Suppl. 2011(191):44-9. doi: 10.1111/j.1600-0404.2011.01543.x.
4
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5
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