Graziano Vincenzo, Buccelli Claudio, Capasso Emanuele, De Micco Francesco, Casella Claudia, Di Lorenzo Pierpaolo, Paternoster Mariano
Department of Advanced Biomedical Sciences, University of Naples "Federico II". Via S. Pansini 5, 80131, Naples, Italy.
Open Med (Wars). 2016 Dec 15;11(1):523-529. doi: 10.1515/med-2016-0090. eCollection 2016.
To overcome kidney donation, the pool of potentially eligible donors has been widened by using suboptimal organs harvested from living donors or cadavers. These organs may engender health complications as age, risk factors, and pathologies of donors fail to meet the standard donor criteria. After examining a wide array of literature on suboptimal kidney transplants, we evidenced two major issues: the lack of standardized terminology and the lack of longterm data on the health outcomes of both suboptimal living donors and recipients. Consequently, surgeons are still unable to provide patients with thorough information to obtain a well-informed consent. Suboptimal kidney transplantation still remains in its experimental stage, thereby raising many ethical and medico-legal concerns. We suggest that one possible solution to overcome some of the ethical shortcomings of suboptimal kidney donations is to provide living donors and recipients honest, accurate, and thorough information about its health risks. To this aim, we advocate adopting a widely standardized terminology that would embrace the whole concept of suboptimal kidney transplantation, increasing the number of future publications on the health outcomes of living donors and recipients, spurring ethical reflection to improve the experience of suboptimal kidney transplantation and reduce the waiting-list for kidney transplantation.
为了克服肾脏供体短缺的问题,人们通过使用从活体供体或尸体获取的次优器官,扩大了潜在合格供体的范围。由于供体的年龄、风险因素和病理状况未达到标准供体标准,这些器官可能会引发健康并发症。在查阅了大量关于次优肾移植的文献后,我们发现了两个主要问题:缺乏标准化术语,以及缺乏关于次优活体供体和受体健康结果的长期数据。因此,外科医生仍然无法向患者提供全面信息以获得充分知情同意。次优肾移植仍处于实验阶段,从而引发了许多伦理和医学法律问题。我们建议,克服次优肾脏捐赠一些伦理缺陷的一个可能解决方案是,向活体供体和受体提供关于其健康风险的诚实、准确和全面的信息。为此,我们主张采用一种广泛标准化的术语,涵盖次优肾移植的整个概念,增加未来关于活体供体和受体健康结果的出版物数量,激发伦理思考,以改善次优肾移植的体验并减少肾移植等待名单。