Ferrari-Dileo G
Invest Ophthalmol Vis Sci. 1988 May;29(5):695-9.
To supplement previous demonstration of angiotensin II and alpha-adrenergic binding sites, beta-adrenergic binding sites for dihydroalprenolol were demonstrated in vessel-free bovine neural retina (Kd = 2.5 nM) and bovine retinal vessels (Kd = 2.8 nM). By means of competition of 3H-dihydroalprenolol with betaxolol and ICI 118,551, approximately equal proportions of Beta 1 and Beta 2 subtypes were found in both the retinal vessels and the neural retina. Further studies are needed to determine the microanatomic location of the binding sites and the physiologic responses, if any, they mediate.
为补充先前对血管紧张素II和α-肾上腺素能结合位点的证明，在无血管的牛神经视网膜（解离常数=2.5纳摩尔）和牛视网膜血管（解离常数=2.8纳摩尔）中证明了二氢心得舒的β-肾上腺素能结合位点。通过3H-二氢心得舒与倍他洛尔和ICI 118,551的竞争，在视网膜血管和神经视网膜中发现了大致相等比例的β1和β2亚型。需要进一步研究以确定结合位点的显微解剖位置以及它们介导的生理反应（如果有的话）。
