Ferrari-Dileo G, Davis E B, Anderson D R
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, FL 33101.
Invest Ophthalmol Vis Sci. 1987 Nov;28(11):1747-51.
Blood vessels isolated from bovine and human retinas have sites that specifically bind 3H-angiotensin II (3H-Ag II) with an apparent dissociation constant (Kd) of 14 nM and a capacity of binding (Bmax) of 0.82 pmol/g. The binding sites for 3H-Ag II appear to be influenced by guanine nucleotides (GTP) and cations (Mg2+ and Na+) in a way that resembles angiotensin II receptors in other tissues. The physiologic effect of blood-borne or locally-formed angiotensin II on retinal blood flow remains to be defined.
从牛和人类视网膜分离出的血管具有特异性结合³H - 血管紧张素II（³H - Ag II）的位点，其表观解离常数（Kd）为14 nM，结合容量（Bmax）为0.82 pmol/g。³H - Ag II的结合位点似乎受鸟嘌呤核苷酸（GTP）和阳离子（Mg²⁺和Na⁺）影响，其方式类似于其他组织中的血管紧张素II受体。血液中或局部形成的血管紧张素II对视网膜血流的生理作用仍有待确定。
